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1. (WO2018083538) ANTI-FAMILY WITH SEQUENCE SIMILARITY 19, MEMBER A5 ANTIBODIES AND METHOD OF USE THEREOF

Pub. No.:    WO/2018/083538    International Application No.:    PCT/IB2017/001490
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Wed Nov 08 00:59:59 CET 2017
IPC: C07K 16/18
C07K 7/00
A61K 39/395
A61K 38/08
A61K 38/10
Applicants: NEURACLE SCIENCE CO., LTD.
Inventors: CHUNG, Jun, Ho
YUNE, Tae Young
KIM, Bongcheol
SEONG, Jae, Young
HWANG, Jong, Ik
JIN, Jun, Yeong
LEE, Jee, Youn
CHO, Eun, Bee
Title: ANTI-FAMILY WITH SEQUENCE SIMILARITY 19, MEMBER A5 ANTIBODIES AND METHOD OF USE THEREOF
Abstract:
The present disclosure provides antibodies that specifically bind to human FAM19A5 and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human FAM19A5 and modulate FAM19A5 activity, e.g., inhibit, suppress, reduce, or reverse the onset of reactive gliosis and/or excessive proliferation of reactive astrocytes, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as central nervous system damage, a degenerative brain disorder, or a neuropathic pain, by administering an antibody that specifically binds to human FAM19A5.