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1. (WO2018083317) AN ENGINEERED MULTI-COMPONENT SYSTEM FOR IDENTIFICATION AND CHARACTERISATION OF T-CELL RECEPTORS, T-CELL ANTIGENS AND THEIR FUNCTIONAL INTERACTION

Pub. No.:    WO/2018/083317    International Application No.:    PCT/EP2017/078377
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Wed Nov 08 00:59:59 CET 2017
IPC: C07K 14/725
C12N 5/0783
C12N 15/85
C12N 15/63
Applicants: GENOVIE AB
Inventors: JARVIS, Reagan Micheal
HILL, Ryan Edward
PASE, Luke Benjamin
Title: AN ENGINEERED MULTI-COMPONENT SYSTEM FOR IDENTIFICATION AND CHARACTERISATION OF T-CELL RECEPTORS, T-CELL ANTIGENS AND THEIR FUNCTIONAL INTERACTION
Abstract:
The present invention relates to a multicomponent system wherein a first component is an engineered TCR-presenting cell (eTPC), designated component A, wherein component A lacks endogenous surface expression of at least one family of analyte antigen-presenting complexes (a APX) and/or analyte antigenic molecule (aAM), and a second component is a genetic donor vector, designated component C, for delivery of ORF encoding analyte TCR chains.