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1. (WO2018083291) S100A8/S100A9-INDUCED IMMUNOTOLERANCE IN NEWBORN SUBJECTS

Pub. No.:    WO/2018/083291    International Application No.:    PCT/EP2017/078291
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Tue Nov 07 00:59:59 CET 2017
IPC: A61K 38/17
G01N 33/96
G01N 33/68
A61P 29/00
Applicants: WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER
MEDIZINISCHE HOCHSCHULE HANNOVER (MHH)
Inventors: VIEMANN, Dorothee
ROTH, Johannes
VOGL, Thomas
Title: S100A8/S100A9-INDUCED IMMUNOTOLERANCE IN NEWBORN SUBJECTS
Abstract:
The present application provides for the use of S100A8 or S100A9 homodimer or S100A8/A9 heterodimer in the prevention or treatment of a NF-κB-associated postnatal inflammatory disorder in a newborn subject. Moreover, the present invention relates to a pharmaceutical composition comprising S100A8 or S100A9 homodimer or S100A8/A9 heterodimer and an in vitro method for evaluating the risk of a newborn subjectfor developing a NF-κB-associated postnatal inflammatory disorder.