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1. (WO2018083258) ONCOLYTIC ADENOVIRUS ENCODING AT LEAST THREE TRANSGENES

Pub. No.:    WO/2018/083258    International Application No.:    PCT/EP2017/078217
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Sat Nov 04 00:59:59 CET 2017
IPC: A61K 35/761
C07K 14/52
C07K 14/705
C07K 16/28
C12N 15/86
Applicants: PSIOXUS THERAPEUTICS LIMITED
Inventors: CHAMPION, Brian Robert
BROMLEY, Alice Claire Noel
Title: ONCOLYTIC ADENOVIRUS ENCODING AT LEAST THREE TRANSGENES
Abstract:
The present disclosure relates to an oncolytic adenovirus, comprising: (i) a first transgene comprising a DNA sequence which encodes a first protein, (ii) a second transgene encoding a protein or fragment comprising a transmembrane domain or GPI anchor, and (iii) a third transgene encoding a third protein; wherein the three transgenes are located between the virus fibre gene L5 and the virus E4 gene and wherein the said transgenes are under the control of a promoter endogenous to the virus, such as the major late promoter, and the relative location of the second transgene is between the first and third transgene, compositions comprising the same; and use of the virus and compositions in treatment, particularly in the treatment of cancer.