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1. (WO2018083257) ONCOLYTIC ADENOVIRUS ENCODING TRANSGENES
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Pub. No.: WO/2018/083257 International Application No.: PCT/EP2017/078215
Publication Date: 11.05.2018 International Filing Date: 03.11.2017
IPC:
C12N 15/86 (2006.01) ,A61K 35/761 (2015.01) ,C07K 16/28 (2006.01) ,C07K 14/705 (2006.01) ,C07K 14/52 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
[IPC code unknown for A61K 35/761]
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
Applicants:
PSIOXUS THERAPEUTICS LIMITED [GB/GB]; PsiOxus House 4-10 The Quadrant, Barton Lane Abingdon Oxon OX14 3YS, GB
Inventors:
BROMLEY, Alice Claire Noel; GB
CHAMPION, Brian Robert; GB
Agent:
STERLING IP LTD; Orion House Bessemer Road Welwyn Garden City AL7 1HH, GB
Priority Data:
1618567.003.11.2016GB
Title (EN) ONCOLYTIC ADENOVIRUS ENCODING TRANSGENES
(FR) ADÉNOVIRUS ONCOLYTIQUES CODANT POUR DES TRANSGÈNES
Abstract:
(EN) The present disclosure relates to a replication competent oncolytic adenovirus comprising a transgene cassette SEQ ID NO: 8 or a sequence 95% identical thereto located between the virus fibre gene L5 and the virus E4 gene and wherein the said transgenes are under the control of a promoter endogenous to the virus, such as the MLP, compositions comprising the same, and use of the said oncolytic adenovirus or composition for treatment.
(FR) La présente invention concerne un adénovirus oncolytique compétent pour la réplication comprenant une cassette de transgène SEQ ID NO: 8 ou une séquence à 95 % identique à cette dernière située entre le gène de fibre virale L5 et le gène E4 viral et lesdits transgènes étant sous le contrôle d'un promoteur endogène au virus, tel que le MLP; des compositions les comprenant; et l'utilisation dudit adénovirus oncolytique ou de ladite composition pour un traitement.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)