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1. (WO2018083223) INHIBITORS OF GANGLIOSIDES METABOLISM FOR THE TREATMENT OF MOTOR NEURON DISEASES
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Pub. No.: WO/2018/083223 International Application No.: PCT/EP2017/078156
Publication Date: 11.05.2018 International Filing Date: 03.11.2017
IPC:
A61K 45/06 (2006.01) ,A61K 31/445 (2006.01) ,A61P 25/10 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
08
Antiepileptics; Anticonvulsants
10
for petit-mal
Applicants:
ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE) [FR/FR]; Hôpital Pitié Salpêtrière 47/83 boulevard de l'Hôpital 75013 Paris, FR
UNIVERSITÉ PIERRE ET MARIE CURIE - PARIS 6 (UPMC) [FR/FR]; 4 place Jussieu 75005 Paris, FR
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE [FR/FR]; 3 rue Michel-Ange 75016 Paris, FR
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) [FR/FR]; 101 rue de Tolbiac 75654 Paris Cedex 13, FR
APHP (ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS) [FR/FR]; 3 avenue Victoria 75001 Paris, FR
ÉCOLE PRATIQUE DES HAUTES ÉTUDES [FR/FR]; Les Patios Saint Jacques 4-14 rue Ferrus 75014 Paris, FR
Inventors:
DARIOS, Frédéric; FR
STEVANIN, Giovanni; FR
MOCHEL, Fanny; FR
BRANCHU, Julien; FR
BOUTRY, Maxime; FR
Agent:
ICOSA; 83 avenue Denfert-Rochereau 75014 Paris, FR
Priority Data:
16197362.304.11.2016EP
Title (EN) INHIBITORS OF GANGLIOSIDES METABOLISM FOR THE TREATMENT OF MOTOR NEURON DISEASES
(FR) INHIBITEURS DU MÉTABOLISME DES GANGLIOSIDES POUR LE TRAITEMENT DE MALADIES DES MOTONEURONES
Abstract:
(EN) The present invention relates to inhibitors of gangliosides metabolism for treating motor neuron diseases, in particular hereditary spastic paraplegias.
(FR) La présente invention concerne des inhibiteurs du métabolisme des gangliosides pour le traitement de maladies des motoneurones, en particulier des paraplégies spastiques familiales.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)