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1. (WO2018083209) WT1 TARGETING DNA VACCINE FOR COMBINATION THERAPY

Pub. No.:    WO/2018/083209    International Application No.:    PCT/EP2017/078124
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Sat Nov 04 00:59:59 CET 2017
IPC: A61K 39/00
A61K 39/395
C07K 16/28
Applicants: VAXIMM AG
Inventors: LUBENAU, Heinz
Title: WT1 TARGETING DNA VACCINE FOR COMBINATION THERAPY
Abstract:
The present invention relates to an attenuated strain of Salmonella comprising at least one copy of a DNA molecule comprising an expression cassette encoding Wilms' Tumor Protein (WT1), for use in the treatment of cancer, wherein the treatment further comprises the administration of at least one checkpoint inhibitor, particularly selected from at least one antibody against PD-1, PD-L1,CTLA-4, IDO, OX-40, GITR, TIM-3, and LAG-3.The present invention further relates to a pharmaceutical composition comprising an attenuated strain of Salmonella comprising at least one copy of a DNA molecule comprising an expression cassette encoding WT1 for use in the treatment of cancer, wherein the treatment further comprises the administration of at least one checkpoint inhibitor, particularly selected from at least one antibody against PD-1, PD-L1,CTLA-4, IDO, OX-40, GITR, TIM-3, and LAG-3.