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1. (WO2018083087) BINDING PROTEINS
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Pub. No.: WO/2018/083087 International Application No.: PCT/EP2017/077891
Publication Date: 11.05.2018 International Filing Date: 31.10.2017
IPC:
C07K 16/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
Applicants:
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED [GB/GB]; 980 Great West Road Brentford, Middlesex TW8 9GS, GB
Inventors:
CHHABRA, Milloni; US
DEMYDCHUK, Yuliya; GB
ENEVER, Carolyn; GB
FAVRE, David; US
GORDON, Shari; US
GRANGER, David; GB
Agent:
GODDARD, Carolyn, Janice; GB
Priority Data:
62/416,21502.11.2016US
62/416,21702.11.2016US
62/416,21802.11.2016US
Title (EN) BINDING PROTEINS
(FR) PROTÉINES DE LIAISON
Abstract:
(EN) The present invention relates to a binding protein specific for at least one of the immune checkpoint receptors PD-1 and LAG-3. In one embodiment, the invention relates to a binding protein specific for both PD-1 and LAG-3. The invention also provides methods of preparing the binding proteins, pharmaceutical compositions containing the binding proteins and medical uses of the binding proteins.
(FR) La présente invention concerne une protéine de liaison spécifique pour au moins l'un des récepteurs de points de contrôle immunitaires PD-1 et LAG-3. Dans un mode de réalisation, l'invention concerne une protéine de liaison spécifique à la fois pour PD-1 et LAG -3. L'invention concerne également des procédés de préparation des protéines de liaison, des compositions pharmaceutiques contenant les protéines de liaison et des utilisations médicales des protéines de liaison.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)