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1. (WO2018083071) IMMUNOLOGICALLY DISCERNIBLE CELL SURFACE VARIANTS FOR USE IN CELL THERAPY

Pub. No.:    WO/2018/083071    International Application No.:    PCT/EP2017/077826
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Tue Oct 31 00:59:59 CET 2017
IPC: C12N 15/10
C12N 15/90
C12Q 1/68
A61K 35/12
C07K 14/705
Applicants: UNIVERSITÄT BASEL
Inventors: JEKER, Lukas
KORNETE, Mara
BORDOLI SCHWEDE, Lorenza
SCHWEDE, Torsten
LEPORE, Rosalba
MATTER MARONE, Romina
RECHER, Mike
Title: IMMUNOLOGICALLY DISCERNIBLE CELL SURFACE VARIANTS FOR USE IN CELL THERAPY
Abstract:
The invention relates to a mammalian cell, particularly a human cell, expressing a first isoform of a surface protein, wherein the first isoform is functionally indistinguishable, but immunologically distinguishable from a second isoform, for use in a medical treatment of a patient having cells expressing the second isoform form of the surface protein. The invention further relates to an agent selected from 1) a compound comprising, or consisting of, an antibody or antibody-like molecule and 2) an immune effector cell bearing an antibody-like molecule or an immune effector cell bearing a chimeric antigen receptor, for use in a method of treatment of a medical condition, wherein the agent is specifically reactive to either a first or a second isoform of a surface protein, wherein the first isoform is functionally indistinguishable, but immunologically distinguishable from the second isoform, and wherein the agent is administered to ablate a cell bearing the isoform that the agent is reactive to.