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1. (WO2018082722) POLYMERIC THERMOPLASTIC BIODEGRADABLE COMPOSITION FOR PRODUCTION OF INSERTS FOR TREATMENT AND PREVENTION OF LOCAL INFECTIONS AND A METHOD OF PREPARATION THEREOF

Pub. No.:    WO/2018/082722    International Application No.:    PCT/CZ2017/050052
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Fri Oct 27 01:59:59 CEST 2017
IPC: A61K 9/00
A61K 47/34
A61K 47/36
Applicants: USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I.
UNIVERZITA KARLOVA
Inventors: SLOUF, Miroslav
KRULIS, Zdenek
OSTAFINSKA, Alexandra
NEVORALOVA, Martina
KREJCIKOVA, Sabina
HORAK, Pavel
POKORNY, David
JAHODA, David
FULIN, Petr
Title: POLYMERIC THERMOPLASTIC BIODEGRADABLE COMPOSITION FOR PRODUCTION OF INSERTS FOR TREATMENT AND PREVENTION OF LOCAL INFECTIONS AND A METHOD OF PREPARATION THEREOF
Abstract:
The invention provides a polymeric thermoplastic biodegradable composition incorporating an antibiotic, in particular for production of inserts for the treatment and prevention of local infections, consisting of (a) at least one plastified polysaccharide component, which is selected from starch, a mixture of starch and maltodextrin, esterified starch, and a mixture of esterified starch and esterified maltodextrin, wherein maltodextrin is a mixture of oligosaccharides having the dextrose equivalent of at most 25, whereas the polysaccharide component further contains an antibiotic, and (b) a polyester component which is poly-ε-caprolactone and/or poly[(ε-caprolactam)-co-(ε-caprolactone)] containing at least 10 % of crystalline phase and having the crystalline phase melting temperature lower than 65 °C, in the weight ratio (a):(b) in the range of 4:1 to 1:9. Additionally, method of preparation of such composition is described.