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1. (WO2018082590) TUMOR IMMUNOTHERAPY TARGET AND APPLICATION THEREOF
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Pub. No.: WO/2018/082590 International Application No.: PCT/CN2017/109031
Publication Date: 11.05.2018 International Filing Date: 02.11.2017
IPC:
A61K 39/395 (2006.01) ,A61K 38/17 (2006.01) ,A61K 45/00 (2006.01) ,A61K 31/7088 (2006.01) ,A61K 48/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 35/04 (2006.01) ,C12Q 1/68 (2018.01) ,C12Q 1/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
04
specific for metastasis
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
02
involving viable micro-organisms
Applicants:
北京蛋白质组研究中心 BEIJING PROTEOME RESEARCH CENTER [CN/CN]; 中国北京市 昌平区科学园路33号 No. 33 Life Science Park, Changping District Beijing 102206, CN
Inventors:
唐丽 TANG, Li; CN
贺福初 HE, Fuchu; CN
柳迪 LIU, Di; CN
陆倩 LU, Qian; CN
Agent:
北京尚诚知识产权代理有限公司 SHANGCHENG & PARTNERS; 中国北京市 平安里西大街28号光大国际中心18层 18th Floor, Ever Bright World Center Building No. 28 West Ping An Li Avenue, Xicheng District Beijing 100034, CN
Priority Data:
201610952945.202.11.2016CN
201610953057.202.11.2016CN
Title (EN) TUMOR IMMUNOTHERAPY TARGET AND APPLICATION THEREOF
(FR) TRAITEMENT CIBLÉ DU CANCER PAR IMMUNOTHÉRAPIE ET SES APPLICATIONS
(ZH) 肿瘤免疫治疗靶标及其应用
Abstract:
(EN) The present invention provides a tumor immunotherapy target and an application thereof, specifically provides an application of a tumor infiltrating-related macrophage expression LSECtin and a tumor expression BTN3A3, separately or together serving as a target, in tumor immunotherapy, and further provides a substance capable of inhibiting activity of the tumor infiltrating-related macrophage expression LSECtin, inhibiting activity of the tumor expression BTN3A3, or inhibiting interaction between the LSECtin and the BTN3A3, comprising an RNA molecule, a fusion protein BTN3A3-Ig, and a monoclonal antibody 5E08, the substance being used as an active ingredient to prepare tumor immunotherapy drugs.
(FR) L’invention concerne un traitement ciblé du cancer par immunothérapie et ses applications, et plus spécifiquement, l’application dans le traitement ciblé du cancer par immunothérapie ciblant la LSECtine exprimée dans les tissus cancéreux à l'aide de macrophages s’infiltrant dans lesdits tissus cancéreux et une BTN3A3 exprimée seule dans les tumeurs ou leur combinaison. L’invention concerne en outre une substance active susceptible d’inhiber la LSECtine exprimée dans les tissus cancéreux à l'aide de macrophages s’infiltrant dans lesdits tissus cancéreux, une substance active susceptible d’inhiber BTN3A3 exprimée seule dans les tumeurs ou une substance à fonction double susceptible d’inhiber la LSECtine et la BTN3A3. L’invention comprend une molécule d’ARN, une protéine hybride BTN3A3-IG et un anticorps monoclonal 5E08 permettant de préparer un médicament, sous forme de molécule active, indiqué pour l’immunothérapie.
(ZH) 本发明提供了肿瘤免疫治疗靶标及其应用,具体地,提供了浸润肿瘤相关巨噬细细胞表达的LSECtin和肿瘤表达BTN3A3单独或共同作为靶点在肿瘤免疫治疗中的应用,并进一步提供了能抑制浸润肿瘤相关巨噬细细胞表达的LSECtin活性、抑制肿瘤表达的BTN3A3活性、或抑制所述LSECtin与BTN3A3相互作用的物质,包括RNA分子、融合蛋白BTN3A3-Ig和单克隆抗体5E08,以其作为活性成分能制备肿瘤免疫治疗药物。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)