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1. (WO2018082587) APPLICATION OF HEDGEHOG PATHWAY INHIBITOR FOR TREATMENT OF FIBROTIC DISEASES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/082587    International Application No.:    PCT/CN2017/109021
Publication Date: 11.05.2018 International Filing Date: 02.11.2017
IPC:
A61K 31/496 (2006.01), A61P 11/00 (2006.01), A61P 37/06 (2006.01)
Applicants: IMPACT THERAPEUTICS, INC [CN/CN]; Room 603, No. 3 Building, 111 Xiangke Road Shanghai 201210 (CN)
Inventors: CAI, Sui Xiong; (CN).
TIAN, Ye Edward; (CN)
Agent: SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC; 435 Guiping Road Shanghai 200233 (CN)
Priority Data:
201610972163.5 04.11.2016 CN
Title (EN) APPLICATION OF HEDGEHOG PATHWAY INHIBITOR FOR TREATMENT OF FIBROTIC DISEASES
(FR) APPLICATION D'UN INHIBITEUR DE LA VOIE HEDGEHOG SERVANT AU TRAITEMENT DE MALADIES FIBROTIQUES
(ZH) Hedgehog通路抑制剂在治疗纤维化疾病中的应用
Abstract: front page image
(EN)The present invention relates to an application of a hedgehog pathway inhibitor for the treatment of fibrotic diseases. Specifically, provided in the present invention is a method for treatment or prevention of fibrotic diseases, the method comprising administering an effective amount of a hedgehog pathway inhibitor to a subject in need thereof, the hedgehog pathway inhibitor being a compound of the following formula (I), or a pharmaceutically acceptable salt or prodrug thereof, ring C, D1-D4, Q1, Q2, and R5 being defined herein.
(FR)La présente invention concerne une application d'un inhibiteur de la voie hedgehog servant au traitement de maladies fibrotiques. Plus particulièrement, la présente invention concerne une méthode de traitement ou de prévention de maladies fibrotiques, la méthode comprenant l'administration d'une quantité efficace d'un inhibiteur de la voie hedgehog au patient en ayant besoin, l'inhibiteur de la voie hedgehog étant un composé de formule suivante (I), ou un sel ou promédicament de qualité pharmaceutique de ce dernier, le cycle C, D1-D4, Q1, Q2 et R5 étant définis dans la description.
(ZH)本发明涉及Hedgehog通路抑制剂在治疗纤维化疾病中的应用。具体而言,本发明提供了一种治疗或预防纤维化疾病的方法,所述方法包括向有需求的受试者施用有效量的hedgehog通路抑制剂,其中所述hedgehog通路抑制剂为下式(I)的化合物,或其可药用盐或前药,其中环C,D1-D4,Q1,Q2和R5为本文所定义。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)