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1. (WO2018082567) HIGHLY-EFFICIENT IDO/TDO DUAL INHIBITOR IN NITROGEN-CONTAINING HETEROCYCLIC HELICAL STRUCTURE

Pub. No.:    WO/2018/082567    International Application No.:    PCT/CN2017/108941
Publication Date: Sat May 12 01:59:59 CEST 2018 International Filing Date: Thu Nov 02 00:59:59 CET 2017
IPC: C07D 487/10
A61K 31/4192
A61K 31/4188
A61K 31/4439
A61P 35/00
Applicants: SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES
中国科学院上海有机化学研究所
Inventors: WANG, Zhaoyin
王召印
GUO, Wei
郭巍
ZHU, Jidong
朱继东
HU, Xinbo
胡新波
Title: HIGHLY-EFFICIENT IDO/TDO DUAL INHIBITOR IN NITROGEN-CONTAINING HETEROCYCLIC HELICAL STRUCTURE
Abstract:
The present invention relates to a highly-efficient IDO/TDO dual inhibitor in a nitrogen-containing heterocyclic helical structure, and in particular, to a compound represented by formula (I) or pharmaceutically acceptable salts thereof, stereoisomers thereof, or tautomers thereof, or a prodrug thereof. The compound represented by formula (I) of the present invention can be used as an indoleamine-2,3-dioxygenase inhibitor and tryptophan-2,3-dioxygenase for preparing drugs for preventing and/or treating indoleamine-2,3-dioxygenase and tryptophan-2,3-dioxygenase mediated diseases.