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1. (WO2018082444) PYRAZOLOPYRIMIDINE COMPOUND AS PI3K INHIBITOR AND USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/082444 International Application No.: PCT/CN2017/106694
Publication Date: 11.05.2018 International Filing Date: 18.10.2017
IPC:
C07D 487/04 (2006.01) ,C07D 519/00 (2006.01) ,A61K 31/519 (2006.01) ,A61P 35/00 (2006.01) ,A61P 35/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
519
Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
02
specific for leukemia
Applicants: YE, Baohuan[CN/CN]; CN
Inventors: YE, Baohuan; CN
Agent: SHENZHEN TALENT PATENT SERVICE; B, 20/F, Building B, Lvjing Square 6009 Shennan Middle Road, Futian District Shenzhen, Guangdong 518000, CN
Priority Data:
201610945311.402.11.2016CN
201710954238.113.10.2017CN
Title (EN) PYRAZOLOPYRIMIDINE COMPOUND AS PI3K INHIBITOR AND USE THEREOF
(FR) COMPOSÉ DE PYRAZOLOPYRIMIDINE EN TANT QU'INHIBITEUR DE PI3K ET SON UTILISATION
(ZH) 吡唑并嘧啶化合物作为PI3K抑制剂及其应用
Abstract:
(EN) The present invention relates to the pyrazolopyrimidine compound of formula (I) and a pharmaceutically-acceptable salt thereof. Such compounds can be used to inhibit the activity of a fat kinase PI3K, and can also be used to treat diseases mediated by PI3K, such as cancers, inflammation and autoimmune diseases. The present invention also relates to a pharmaceutical composition containing such compounds, a method for preparing such compounds and the use of such compounds or pharmaceutical composition in preparing drugs for treating cancers, inflammation and autoimmune diseases mediated by PI3K.
(FR) La présente invention concerne le composé de pyrazolopyrimidine de formule (I) et un sel pharmaceutiquement acceptable de celui-ci. De tels composés peuvent être utilisés pour inhiber l'activité d'une protéine kinase PI3K, et peuvent également être utilisés pour traiter des maladies induites par PI3K, telles que des cancers, une inflammation et des maladies auto-immunes. La présente invention concerne également une composition pharmaceutique contenant de tels composés, un procédé de préparation de tels composés et l'utilisation de tels composés ou composition pharmaceutique dans la préparation de médicaments pour le traitement de cancers, d'inflammations et de maladies auto-immunes induites par PI3K.
(ZH) 本发明涉及式(I)的吡唑并嘧啶化合物及其药学上可接受的盐。这类化合物可用于抑制脂肪激酶PI3K的活性,也可用于治疗由PI3K介导的疾病,如癌症和炎症及自身免疫性疾病。本发明还涉及含有这类化合物的药物组合物,制备这类化合物的方法以及这类化合物或药物组合物在制备用于治疗由PI3K介导的癌症和炎症及自身免疫性疾病的药物中的应用。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)