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1. (WO2018081789) ENGINEERED ARTIFICIAL ANTIGEN PRESENTING CELLS FOR TUMOR INFILTRATING LYMPHOCYTE EXPANSION
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Pub. No.: WO/2018/081789 International Application No.: PCT/US2017/059271
Publication Date: 03.05.2018 International Filing Date: 31.10.2017
IPC:
C12N 5/0784 (2010.01) ,C12N 5/078 (2010.01) ,C12N 5/0783 (2010.01) ,A61K 39/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0784
Dendritic cells; Progenitors thereof
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0783
T cells; NK cells; Progenitors of T or NK cells
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
Applicants:
IOVANCE BIOTHERAPEUTICS, INC. [US/US]; 999 Skyway Road Suite 150 San Carlos, CA 94070, US
Inventors:
VEERAPATHARAN, Anand; US
GOKULDASS, Aishwarya; IN
RABINOVICH, Brian; US
LOTZE, Michael, T.; US
Agent:
WALLS, Thomas, H.; US
BEARDELL, Louis, W.; US
DAVIS, Kenneth, J.; US
BERNSTEIN, David, P.; US
CHAI, Deping; US
Priority Data:
62/415,27431.10.2016US
62/438,60023.12.2016US
62/475,05322.03.2017US
62/481,83105.04.2017US
Title (EN) ENGINEERED ARTIFICIAL ANTIGEN PRESENTING CELLS FOR TUMOR INFILTRATING LYMPHOCYTE EXPANSION
(FR) CELLULES PRÉSENTATRICES D'ANTIGÈNES ARTIFICIELLES GÉNÉTIQUEMENT MODIFIÉES POUR L'EXPANSION DE L'INFILTRATION LYMPHOCYTAIRE INTRATUMORALE
Abstract:
(EN) In some embodiments, compositions and methods relating to isolated artificial antigen presenting cells (aAPCs) are disclosed, including aAPCs comprising a myeloid cell transduced with one or more viral vectors, such as a MOLM-14 or a EM-3 myeloid cell, wherein the myeloid cell endogenously expresses HLA-A/B/C, ICOS-L, and CD58, and wherein the one or more viral vectors comprise a nucleic acid encoding CD86 and a nucleic acid encoding 4-lBBL and/or OX40L and transduce the myeloid cell to express CD86 and 4-lBBL and/or OX40L proteins. In some embodiments, methods of expanding tumor infiltrating lymphocytes (TILs) with aAPCs and methods of treating cancers using TILs after expansion with aAPCs are also disclosed.
(FR) Dans certains modes de réalisation, l'invention concerne des compositions et des méthodes faisant appel à des cellules présentatrices d'antigènes artificielles isolées (aAPC), dont des aAPC comprenant une cellule myéloïde transduite à l'aide d'un ou de plusieurs vecteurs viraux, telle qu'une cellule myéloïde MOLM-14 ou EM-3, où la cellule myéloïde exprime de manière endogène HLA-A/B/C, ICOS-L, et CD58, et où le ou les vecteurs viraux comprennent un acide nucléique codant pour CD86 et un acide nucléique codant pour 4-lBBL et/ou OX40L et transduisent la cellule myéloïde pour qu'elle exprime des protéines CD86 et 4-lBBL et/ou OX40L. Dans certains modes de réalisation, des procédés d'expansion de l'infiltration lymphocytaire intratumorale (TIL) à l'aide d'aAPC et des méthodes de traitement des cancers à l'aide des TIL après expansion à l'aide d'aAPC sont en outre décrits.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)