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1. (WO2018081738) TREATMENT OF DISEASES ASSOCIATED WITH ACTIVATED IRAK
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Pub. No.: WO/2018/081738 International Application No.: PCT/US2017/059091
Publication Date: 03.05.2018 International Filing Date: 30.10.2017
IPC:
A61P 1/16 (2006.01) ,A61P 3/00 (2006.01) ,A61P 7/00 (2006.01) ,A61P 9/04 (2006.01) ,C12Q 1/68 (2018.01) ,G01N 33/48 (2006.01)
[IPC code unknown for A61P 1/16][IPC code unknown for A61P 3][IPC code unknown for A61P 7][IPC code unknown for A61P 9/04][IPC code unknown for C12Q 1/68][IPC code unknown for G01N 33/48]
Applicants:
CHILDREN'S HOSPITAL MEDICAL CENTER [US/US]; 3333 Burnet Avenue Cincinnati, Ohio 45229-3039, US
Inventors:
SMITH, Molly; US
STARCZYNOWSKI, Daniel; US
KOMUROV, Kakajan; US
Agent:
DAVISON, Barry L.; US
ADAMS, Dylan O.; US
ADAMS, Scott S.; US
ALBERT, Philip H.; US
BRUNNER, Jaron K.; US
BYER, Benjamin J.; US
CANTRELL, Tyler C.; US
CHANG, Jack; US
CHOU, Timothy; US
COLBURN, Heather M.; US
DAGGETT, David K.; US
DONOHUE, Michael J.; US
GIBBS, Richard A.; US
JOHNSON, Bruce L.; US
LIM, Susuk; US
MOERSFELDER, Matthew E.; US
MONTAGUE, Joanne; US
RABURN, Greg A.; US
ROGGE, Mark H.; US
RONDEAU JR, George C.; US
TOLSTEDT, Jonathan L.; US
VAGNER, Allison; US
WILSON, Erica; US
Priority Data:
62/414,05828.10.2016US
62/429,28902.12.2016US
Title (EN) TREATMENT OF DISEASES ASSOCIATED WITH ACTIVATED IRAK
(FR) TRAITEMENT DE MALADIES ASSOCIÉES À IRAK ACTIVÉ
Abstract:
(EN) Methods and compositions disclosed herein generally relate to compositions and methods for the treatment of cancers, including disorders such as myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). In particular, the invention relates to determining an individual in need of treatment who can be treated with an IRAK1/4 inhibitor.
(FR) Les méthodes et compositions de l'invention se rapportent généralement à des compositions et méthodes pour le traitement de cancers, y compris des troubles tels que le syndrome myélodysplasique (MDS) et la leucémie myéloïde aiguë (AML). En particulier, l'invention concerne la détermination d'un individu ayant besoin d'un traitement qui peut être traité avec un inhibiteur d'IRAK1/4.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)