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1. (WO2018081728) COMPOSITIONS FOR GENOME EDITING

Pub. No.:    WO/2018/081728    International Application No.:    PCT/US2017/059077
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Tue Oct 31 00:59:59 CET 2017
IPC: A61K 48/00
C12N 15/00
C12N 15/87
C07H 21/04
Applicants: EMENDOBIO INC.
Inventors: BARAM, David
IZHAR, Lior
EMMANUEL, Rafi
Title: COMPOSITIONS FOR GENOME EDITING
Abstract:
The present invention relates to compositions and methods for increasing the rate of site specific insertion of a donor DNA sequence to the genome. More specifically, the method introduces a donor DNA template containing at least one transcription factor binding site to a cell in order to favor specific insertion of a donor template sequence at a target site by homology directed repair (HDR).