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1. (WO2018081719) SMALL MOLECULE INHIBITORS OF NEK2 AND USES THEREOF
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Pub. No.: WO/2018/081719 International Application No.: PCT/US2017/059061
Publication Date: 03.05.2018 International Filing Date: 30.10.2017
IPC:
A61P 35/00 (2006.01) ,A61K 31/437 (2006.01) ,C07D 471/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA [US/US]; The University of Arizona, Tech Launch Arizona, University Services Annex, 4th Floor, P.O. Box 210300A Tucson, Arizona 85721, US
EAST CHINA NORMAL UNIVERSITY [CN/CN]; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development East China Normal University Science Building B-1509 3663 North Zhongshan Road, Shanghai, 20062, CN
THE UAB RESEARCH FOUNDATION [US/US]; 701 20th Street South, Administration Building 770 Birmingham, Alabama 35294-0107, US
THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE [US/US]; 445 N. Fifth Street, Suite 600 Phoenix, Arizona 85004, US
Inventors:
LI, Hong-yu; US
FRETT, Brendan; US
NAKANO, Ichiro; US
HAN, Haiyong; US
HU, Wenhao; CN
Agent:
GOETZ, Robert A.; US
Priority Data:
62/415,14431.10.2016US
Title (EN) SMALL MOLECULE INHIBITORS OF NEK2 AND USES THEREOF
(FR) INHIBITEURS À PETITES MOLÉCULES DE NEK2 ET UTILISATIONS ASSOCIÉES
Abstract:
(EN) This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having an imidazole pyrimidine structure which function as inhibitors of NEK2 protein, and their use as therapeutics for the treatment of cancer and other diseases.
(FR) La présente invention concerne le domaine de la chimie médicale. En particulier, l'invention concerne une nouvelle classe de petites molécules qui présentent la structure d’imidazole pyrimidine et qui agissent comme inhibiteurs de la protéine NEK2, ainsi que leur utilisation comme agents thérapeutiques pour le traitement du cancer et d'autres maladies.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)