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1. (WO2018081661) HDAC INHIBITOR COMPOSITIONS FOR REACTIVATION OF THE X CHROMOSOME
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Pub. No.: WO/2018/081661 International Application No.: PCT/US2017/058900
Publication Date: 03.05.2018 International Filing Date: 27.10.2017
IPC:
A61K 31/16 (2006.01) ,A61K 31/165 (2006.01) ,A61K 31/343 (2006.01) ,A61K 48/00 (2006.01) ,C07H 21/02 (2006.01) ,C12N 15/00 (2006.01)
[IPC code unknown for A61K 31/16][IPC code unknown for A61K 31/165][IPC code unknown for A61K 31/343][IPC code unknown for A61K 48][IPC code unknown for C07H 21/02][IPC code unknown for C12N 15]
Applicants:
CALIFORNIA INSTITUTE OF TECHNOLOGY [US/US]; 1200 E. California Boulevard MC 6-32 Pasadena, California 91125, US
Inventors:
GUTTMAN, Mitchell; US
CHEN, Chun-Kan; US
Agent:
BALLEW CHANG, Nicole; US
Priority Data:
62/413,92827.10.2016US
Title (EN) HDAC INHIBITOR COMPOSITIONS FOR REACTIVATION OF THE X CHROMOSOME
(FR) COMPOSITIONS D'INHIBITEUR DE HDAC POUR LA RÉACTIVATION DU CHROMOSOME X
Abstract:
(EN) A reactivation composition for activating or re-activating expression of a silenced X chromosome gene in a cell includes a non-cytotoxic histone deacetylase (HDAC) inhibitor. The reactivation composition includes the non-cytotoxic HDAC inhibitor and may further include a DNA methylation inhibitor. A method of activating or re-activating expression of a silenced X chromosome gene in a cell includes administering a reactivation composition including a non-cytotoxic HDAC inhibitor. The method of activating or re-activating expression of a silenced X chromosome gene may further includes administering a reactivation composition that includes a non-cytotoxic HDAC inhibitor and an inhibitor of DNA methylation.
(FR) L'invention concerne une composition de réactivation pour activer ou réactiver l'expression d'un gène du chromosome X silencieux dans une cellule comprenant un inhibiteur de l'histone désacétylase (HDAC) non cytotoxique. La composition de réactivation comprend l'inhibiteur de HDAC non cytotoxique et peut en outre comprendre un inhibiteur de méthylation de l'ADN. L'invention concerne un procédé d'activation ou de réactivation de l'expression d'un gène du chromosome X silencieux dans une cellule, comprenant l'administration d'une composition de réactivation comprenant un inhibiteur de HDAC non cytotoxique. Le procédé d'activation ou de réactivation de l'expression d'un gène du chromosome X silencieux peut en outre comprendre l'administration d'une composition de réactivation qui comprend un inhibiteur de HDAC non cytotoxique et un inhibiteur de la méthylation de l'ADN.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)