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1. (WO2018081642) ANTI-APOE ANTIBODIES
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Pub. No.: WO/2018/081642 International Application No.: PCT/US2017/058874
Publication Date: 03.05.2018 International Filing Date: 27.10.2017
IPC:
A61K 9/127 (2006.01) ,A61K 31/192 (2006.01) ,A61K 39/395 (2006.01)
[IPC code unknown for A61K 9/127][IPC code unknown for A61K 31/192][IPC code unknown for A61K 39/395]
Applicants:
WASHINGTON UNIVERSITY [US/US]; One Brookings Drive St. Louis, Missouri 63130, US
DENALI THERAPEUTICS INC. [US/US]; 151 Oyster Point Blvd., 2nd Floor South San Francisco, California 94080, US
Inventors:
HOLTZMAN, David; US
JIANG, Hong; US
LIAO, Fan; US
BIEN-LY, Thu Nga; US
DENNIS, Mark S.; US
GUO, Jing; US
SILVERMAN, Adam P.; US
WATTS, Ryan J.; US
ZHANG, Yin; US
Agent:
RILEY-VARGAS, Rebecca; US
BISSEN, Shirley T.; US
JOHNSON, Charles A.; US
ROBERTS, Brett J.; US
NEALEY, Tara A.; US
KREPEL, Allison; US
DEAN, III, Elton F.; US
DOTY, Kathryn; US
KIRLEY, J. Morgan; US
Priority Data:
62/414,41328.10.2016US
62/533,33617.07.2017US
Title (EN) ANTI-APOE ANTIBODIES
(FR) ANTICORPS ANTI-APOE
Abstract:
(EN) The present disclosure encompasses compositions and methods for effectively treating at least one symptom or sign of A plaque or cerebral amyloid angiopathy (CAA) associated symptoms, or for decreasing amyloid plaque load or CAA load. The method comprises administering an effective amount of an anti-ApoE antibody to a mammalian subject, such as to a human.
(FR) La présente invention concerne des compositions et des méthodes pour le traitement efficace d'au moins un symptôme ou signe de plaque A ou de symptômes associés à l'angiopathie amyloïde cérébrale (CAA), ou pour diminuer la charge de plaque amyloïde ou la charge de CAA. La méthode comprend l'administration d'une quantité efficace d'un anticorps anti-ApoE à un sujet mammifère, par exemple à un être humain.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)