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1. (WO2018081621) METHODS OF TREATING UROTHELIAL CARCINOMA USING AN ANTI-PD-1 ANTIBODY

Pub. No.:    WO/2018/081621    International Application No.:    PCT/US2017/058846
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Sat Oct 28 01:59:59 CEST 2017
IPC: C07K 16/28
A61P 35/00
A61K 39/00
Applicants: BRISTOL-MYERS SQUIBB COMPANY
Inventors: TSCHAIKA, Marina
Title: METHODS OF TREATING UROTHELIAL CARCINOMA USING AN ANTI-PD-1 ANTIBODY
Abstract:
This disclosure provides a method for treating a subject afflicted with a urothelial carcinoma or cancer derived therefrom, which method comprises administering to the subject an antibody or an antigen-binding portion thereof that specifically binds to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity or the combination of (a) an antibody or an antigen-binding portion thereof that specifically binds to a PD-1 receptor and inhibits PD-1 activity; and (b) an antibody or an antigen-binding portion thereof that specifically binds to a Cytotoxic T- Lymphocyte Antigen-4 (CTLA-4) and inhibits CTLA-4 activity.