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1. (WO2018081575) METHODS AND COMPOSITIONS FOR IDENTIFYING AND TREATING PATIENTS WITH SMALL CELL LUNG CANCER

Pub. No.:    WO/2018/081575    International Application No.:    PCT/US2017/058782
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Sat Oct 28 01:59:59 CEST 2017
IPC: A01K 67/027
C12N 15/09
C12Q 1/02
Applicants: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventors: OLIVER, Trudy
SOS, Martin
WECHSLER-REYA, Rob
Title: METHODS AND COMPOSITIONS FOR IDENTIFYING AND TREATING PATIENTS WITH SMALL CELL LUNG CANCER
Abstract:
Described herein are methods and compositions useful in detecting, diagnosing and treating small cell lung cancer. Transgenic animal models and cell lines are disclosed for the study of a small cell lung cancer subtype. Methods of screening and identifying active agents for the treatment of a small cell lung cancer subtype as well as methods of identifying patients susceptible to treatment with aurora kinase inhibitors are also provided.