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1. (WO2018081534) ASSAY FOR EXO-SITE BINDING MOLECULES
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Pub. No.: WO/2018/081534 International Application No.: PCT/US2017/058722
Publication Date: 03.05.2018 International Filing Date: 27.10.2017
IPC:
C40B 20/04 (2006.01) ,C40B 40/10 (2006.01) ,C40B 40/14 (2006.01)
C CHEMISTRY; METALLURGY
40
COMBINATORIAL TECHNOLOGY
B
COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
20
Methods specially adapted for identifying library members
04
Identifying library members by means of a tag, label, or other readable or detectable entity associated with the library members, e.g. decoding processes
C CHEMISTRY; METALLURGY
40
COMBINATORIAL TECHNOLOGY
B
COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
40
Libraries per se, e.g. arrays, mixtures
04
Libraries containing only organic compounds
10
Libraries containing peptides or polypeptides, or derivatives thereof
C CHEMISTRY; METALLURGY
40
COMBINATORIAL TECHNOLOGY
B
COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
40
Libraries per se, e.g. arrays, mixtures
04
Libraries containing only organic compounds
14
Libraries containing macromolecular compounds and not covered by groups C40B40/06-C40B40/12124
Applicants:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, MA 02138, US
Inventors:
MAIANTI, Juan, Pablo; US
LIU, David, R.; US
Agent:
BAKER, C., Hunter; US
Priority Data:
62/414,64028.10.2016US
Title (EN) ASSAY FOR EXO-SITE BINDING MOLECULES
(FR) ESSAI POUR MOLÉCULES DE LIAISON EXO-SITE
Abstract:
(EN) Methods for the identification of agents the bind to exo-sites of proteins are provided. Agents identified by the methods described herein and pharmaceutical compositions comprising the identified agents are also provided. Methods of using an identified agent for the treatment or prevention of a disease, disorder, or condition are also provided, including methods of treating or preventing a disease associated with reduced, elevated, or ectopic expression or aberrant activity of a protein comprising an exo-site.
(FR) Cette invention concerne des procédés d'identification d'agents qui se lient à des exo-sites de protéines. L'invention concerne en outre les agents identifiés par les procédés selon l'invention et des compositions pharmaceutiques comprenant les agents identifiés. L'invention concerne enfin des procédés d'utilisation d'un agent identifié pour le traitement ou la prévention d'une maladie, d'un trouble ou d'une affection, y compris des procédés de traitement ou de prévention d'une maladie associée à une sécrétion réduite, élevée ou ectopique ou une activité aberrante d'une protéine comprenant un exo-site.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)