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1. (WO2018081531) METHODS FOR HUMAN T-CELL ACTIVATION
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Pub. No.: WO/2018/081531 International Application No.: PCT/US2017/058719
Publication Date: 03.05.2018 International Filing Date: 27.10.2017
IPC:
C07K 16/28 (2006.01) ,A61K 39/395 (2006.01)
[IPC code unknown for C07K 16/28][IPC code unknown for A61K 39/395]
Applicants:
ARIAD PHARMACEUTICALS, INC. [US/US]; 40 Landsdowne Street Cambridge, MD 02139, US
Inventors:
GONZALVEZ, Francois; US
PRITCHARD, Justin, R.; US
GRISHKEVICH, Vladislav; US
Agent:
BYCHOWSKI, Meaghan, E.; US
RUBENSTEIN, Kenneth; US
BAUER, Steven; US
COUSINS, Abigail; US
SHALEK, James; US
Priority Data:
62/414,34528.10.2016US
Title (EN) METHODS FOR HUMAN T-CELL ACTIVATION
(FR) MÉTHODESS D'ACTIVATION DE LYMPHOCYTES T HUMAINS
Abstract:
(EN) The present invention provides, among other things, methods of increasing T-cell activation in a subject, comprising administering to the subject a composition that inhibits hematopoietic progenitor kinase 1 (HPKl). The composition may comprise, for example, a small molecule HPKl inhibitor. The method may further comprise administering to the subject an anti-CTLA-4 antibody and/or an anti-PD-1 antibody.
(FR) La présente invention concerne, entre autres, des méthodes d'augmentation de l'activation des lymphocytes T chez un sujet, comprenant l'administration au sujet d'une composition qui Inhibe la kinase 1 progénitrice hématopoïétique (HPKl). La composition peut comprendre, par exemple, un inhibiteur de HPKl à petites molécules. La méthode peut en outre comprendre l'administration au sujet d'un anticorps anti-CTLA -4 et/ou d'un anticorps anti-PD-1.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)