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1. (WO2018081530) COMPOSITIONS AND METHODS FOR TREATING EZH2-MEDIATED CANCER
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/081530    International Application No.:    PCT/US2017/058718
Publication Date: 03.05.2018 International Filing Date: 27.10.2017
IPC:
C07D 401/12 (2006.01), C07D 409/14 (2006.01), C07D 405/14 (2006.01)
Applicants: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI [US/US]; One Gustave L. Levy Place Box 1030 New York, New York 10029 (US)
Inventors: JIN, Jian; (US).
PARSONS, Ramon; (US).
STRATIKOPOULOS, Ilias; (US).
YANG, Xiaobao; (US).
MA, Anqi; (US)
Agent: WONG, Albert; (US).
LODOVICE, Ian J.; (US)
Priority Data:
62/414,195 28.10.2016 US
Title (EN) COMPOSITIONS AND METHODS FOR TREATING EZH2-MEDIATED CANCER
(FR) COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DU CANCER À MÉDIATION PAR L'EZH2
Abstract: front page image
(EN)Methods for designing bivalent compounds which selectively degrade/disrupt EZH2 and compositions and methods of using such degraders/disruptors to treat EZH2-mediated cancer are provided.
(FR)L'invention concerne des procédés de conception de composés bivalents qui dégradent/interrompent sélectivement l'EZH 2, des compositions et des procédés d'utilisation de tels agents de dégradation/d'interruption pour traiter le cancer à médiation par l'EZH2.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)