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1. (WO2018081504) CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING HERPES SIMPLEX VIRUS

Pub. No.:    WO/2018/081504    International Application No.:    PCT/US2017/058670
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Sat Oct 28 01:59:59 CEST 2017
IPC: C12N 15/113
A61P 31/22
Applicants: EDITAS MEDICINE, INC.
DUKE UNIVERSITY
Inventors: FRIEDLAND, Ari, E.
O'DONNELL, Penrose
BUMCROT, David, A.
CULLEN, Bryan, R.
Title: CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING HERPES SIMPLEX VIRUS
Abstract:
Disclosed herein are genome editing systems and genetic constructs that targets a herpes simplex virus (HSV) viral gene comprising one Cas9 molecule, and a gRNA molecule, and compositions and cells comprising such genome editing systems and genetic constructs. Also provided are methods for using the genome editing systems, genetic constructs, compositions and cells for genome engineering (e.g., altering a HSV viral gene), and for preventing, treating or reducing HSV infection.