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1. (WO2018081460) COMPOSITION COMPRISING AN ANTI-ABETA PROTOFIBRIL ANTIBODY AND A BETA-SECRETASE BACE1 INHIBITOR FOR THE TREATMENT OF ALZHEIMER'S DISEASE
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Pub. No.: WO/2018/081460 International Application No.: PCT/US2017/058587
Publication Date: 03.05.2018 International Filing Date: 26.10.2017
IPC:
C07K 14/47 (2006.01) ,C07K 16/18 (2006.01) ,A61K 31/404 (2006.01) ,A61K 39/395 (2006.01)
Applicants: SATLIN, Andrew[US/US]; US
FUKUSHIMA, Tatsuto[JP/JP]; JP
EISAI R&D MANAGEMENT CO., LTD.[JP/JP]; 6-10 Koishikawa, 4-Chome Bunkyo-ku, Tokyo, 112-8088, JP
Inventors: SATLIN, Andrew; US
FUKUSHIMA, Tatsuto; JP
Agent: MACALPINE, Jill, K.; US
Priority Data:
62/413,96127.10.2016US
62/415,16531.10.2016US
Title (EN) COMPOSITION COMPRISING AN ANTI-ABETA PROTOFIBRIL ANTIBODY AND A BETA-SECRETASE BACE1 INHIBITOR FOR THE TREATMENT OF ALZHEIMER'S DISEASE
(FR) COMPOSITION COMPRENANT UN ANTICORPS ANTI-PROTOFIBRILLE A BÊTA ET UN INHIBITEUR DE LA BÊTA-SÉCRÉTASE BACE1 POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
Abstract: front page image
(EN) Methods and combination therapies for treating, preventing, and/or delaying the onset and/or development of Alzheimer's disease using an anti-Αβ protofibril antibody (such as, for example, BAN2401 ) and N-[3-((4aS,5R,7aS)-2- amino-5-methyl-4a,5,7,7a- tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4- fluorophenyl]-5-difluoromethylpyrazine-2-carboxamide and/or a pharmaceutically acceptable salt thereof (Compound X) are provided.
(FR) L'invention concerne des procédés et des polythérapies pour le traitement, la prévention et/ou le retardement de l'apparition et/ou du développement de la maladie d'Alzheimer à l'aide d'un anticorps anti-protofibrille Αβ (tel que, par exemple, BAN2401) et N- [3- ((4aS,5R,7aS)-2-amino-5-méthyl -4a,5,7,7 a-tétrahydro -4H-furo [3,4-d] [1,3] thiazin -7a-yl)-4-fluorophényl]-5-difluorométhylpyrazine-2-carboxamide et/ou un sel pharmaceutiquement acceptable de celui-ci (composé X).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)