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1. (WO2018081460) COMPOSITION COMPRISING AN ANTI-ABETA PROTOFIBRIL ANTIBODY AND A BETA-SECRETASE BACE1 INHIBITOR FOR THE TREATMENT OF ALZHEIMER'S DISEASE

Pub. No.:    WO/2018/081460    International Application No.:    PCT/US2017/058587
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Fri Oct 27 01:59:59 CEST 2017
IPC: C07K 14/47
C07K 16/18
A61K 31/404
A61K 39/395
Applicants: EISAI R&D MANAGEMENT CO., LTD.
SATLIN, Andrew
FUKUSHIMA, Tatsuto
Inventors: SATLIN, Andrew
FUKUSHIMA, Tatsuto
Title: COMPOSITION COMPRISING AN ANTI-ABETA PROTOFIBRIL ANTIBODY AND A BETA-SECRETASE BACE1 INHIBITOR FOR THE TREATMENT OF ALZHEIMER'S DISEASE
Abstract:
Methods and combination therapies for treating, preventing, and/or delaying the onset and/or development of Alzheimer's disease using an anti-Αβ protofibril antibody (such as, for example, BAN2401 ) and N-[3-((4aS,5R,7aS)-2- amino-5-methyl-4a,5,7,7a- tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4- fluorophenyl]-5-difluoromethylpyrazine-2-carboxamide and/or a pharmaceutically acceptable salt thereof (Compound X) are provided.