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1. (WO2018081451) SMALL MOLECULE PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) INHIBITORS AND METHODS OF TREATMENT
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/081451    International Application No.:    PCT/US2017/058572
Publication Date: 03.05.2018 International Filing Date: 26.10.2017
IPC:
A61K 31/416 (2006.01), A61K 31/4439 (2006.01)
Applicants: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US/US]; 518 Indiana Avenue Indianapolis, Indiana 46202 (US)
Inventors: LU, Tao; (US).
PRABHU, Lakshmi Milind; (US)
Agent: HASAN, Salim A.; (US).
HARRELL, Kristen; (US)
Priority Data:
62/413,341 26.10.2016 US
62/534,969 20.07.2017 US
Title (EN) SMALL MOLECULE PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) INHIBITORS AND METHODS OF TREATMENT
(FR) INHIBITEURS DE LA PROTÉINE ARGININE MÉTHYLTRANSFÉRASE 5 (PRMT5) DE TYPE PETITES MOLÉCULES, ET MÉTHODES DE TRAITEMENT
Abstract: front page image
(EN)Provided are compounds of formulas (I), (II), (III), and (IV), which effectively inhibit protein arginine methyltransferase 5 (PRMT5). Also provided are methods of using the compounds, including a method of treating cancer, a method of inhibiting the activity of PRMT5 in a cell, and a method of treating a disease associated with increased activity of PRMT5.
(FR)L'invention concerne des composés de formules (I), (II), (III) et (IV), qui inhibent efficacement la protéine arginine méthyltransférase 5 (PRMT5). L'invention concerne également des méthodes d'utilisation des composés, y compris une méthode de traitement du cancer, une méthode d'inhibition de l'activité de la PRMT5 dans une cellule, et une méthode de traitement d'une maladie associée à une augmentation de l'activité de la PRMT5.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)