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1. (WO2018081401) METHOD FOR INCREASING CELL PROLIFERATION IN PANCREATIC BETA CELLS, TREATMEN T METHOD.AND COMPOSITION

Pub. No.:    WO/2018/081401    International Application No.:    PCT/US2017/058498
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Fri Oct 27 01:59:59 CEST 2017
IPC: C12N 5/071
A61K 9/50
A61K 9/20
A61K 35/39
A61K 31/4178
A61K 31/36
A61K 31/4164
A61P 3/10
A61P 1/18
Applicants: ICHAN SCHOOL OF MEDICINE AT MOUNT SINAI
Inventors: STEWART, Andrew, F.
WANG, Peng
Title: METHOD FOR INCREASING CELL PROLIFERATION IN PANCREATIC BETA CELLS, TREATMEN T METHOD.AND COMPOSITION
Abstract:
The present invention relates to a method of increasing cell proliferation in a population of pancreatic beta cells and a method of treating a subject for a condition associated with an insufficient level of insulin secretion. Also disclosed is a composition. The composition includes a dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1 A) inhibitor and a transforming growth factor beta (TGFP) superfamily signaling pathway inhibitor.