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1. (WO2018081401) METHOD FOR INCREASING CELL PROLIFERATION IN PANCREATIC BETA CELLS, TREATMEN T METHOD.AND COMPOSITION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/081401    International Application No.:    PCT/US2017/058498
Publication Date: 03.05.2018 International Filing Date: 26.10.2017
IPC:
C12N 5/071 (2010.01), A61K 9/50 (2006.01), A61K 9/20 (2006.01), A61K 35/39 (2015.01), A61K 31/4178 (2006.01), A61K 31/36 (2006.01), A61K 31/4164 (2006.01), A61P 3/10 (2006.01), A61P 1/18 (2006.01)
Applicants: ICHAN SCHOOL OF MEDICINE AT MOUNT SINAI [US/US]; 1 Gustave L. Levy Place New York, NY 10029 (US)
Inventors: STEWART, Andrew, F.; (US).
WANG, Peng; (US)
Agent: TISCHNER, Tate, L.; (US).
GOLDMAN, Michael, L.; (US).
O'GARA, Megan, T.; (US).
CHILDS, Carissa, R.; (US).
MERKEL, Edwin, V.; (US)
Priority Data:
62/413,071 26.10.2016 US
Title (EN) METHOD FOR INCREASING CELL PROLIFERATION IN PANCREATIC BETA CELLS, TREATMEN T METHOD.AND COMPOSITION
(FR) PROCÉDÉ D’AUGMENTATION DE LA PROLIFÉRATION CELLULAIRE DANS LES CELLULES PANCRÉATIQUES BÊTA, PROCÉDÉ DE TRAITEMENT ET COMPOSITION
Abstract: front page image
(EN)The present invention relates to a method of increasing cell proliferation in a population of pancreatic beta cells and a method of treating a subject for a condition associated with an insufficient level of insulin secretion. Also disclosed is a composition. The composition includes a dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1 A) inhibitor and a transforming growth factor beta (TGFP) superfamily signaling pathway inhibitor.
(FR)La présente invention concerne un procédé d’augmentation de la prolifération cellulaire dans une population de cellules pancréatiques bêta et un procédé de traitement d’un sujet pour un état associé à un niveau insuffisant de la sécrétion d’insuline. L’invention concerne également une composition. La composition comprend un inhibiteur à double spécificité de la kinase (1A) régulée par la phosphorylation de la tyrosine (DYRK1 A) et un inhibiteur de la voie de signalisation de la superfamille du facteur de croissance transformant bêta (TGFP).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)