Search International and National Patent Collections
|1. (WO2018081401) METHOD FOR INCREASING CELL PROLIFERATION IN PANCREATIC BETA CELLS, TREATMEN T METHOD.AND COMPOSITION|
|Applicants:||ICHAN SCHOOL OF MEDICINE AT MOUNT SINAI
|Inventors:||STEWART, Andrew, F.
|Title:||METHOD FOR INCREASING CELL PROLIFERATION IN PANCREATIC BETA CELLS, TREATMEN T METHOD.AND COMPOSITION|
The present invention relates to a method of increasing cell proliferation in a population of pancreatic beta cells and a method of treating a subject for a condition associated with an insufficient level of insulin secretion. Also disclosed is a composition. The composition includes a dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1 A) inhibitor and a transforming growth factor beta (TGFP) superfamily signaling pathway inhibitor.