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1. (WO2018081367) CYCLIC PEPTIDE TYROSINE TYROSINE COMPOUNDS AS MODULATORS OF NEUROPEPTIDE Y RECEPTORS

Pub. No.:    WO/2018/081367    International Application No.:    PCT/US2017/058451
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Fri Oct 27 01:59:59 CEST 2017
IPC: A61K 38/12
A61K 38/22
A61K 38/17
C07K 14/575
C07K 14/46
Applicants: JANSSEN PHARMACEUTICA NV
MACIELAG, Mark
Inventors: MACIELAG, Mark
MACIELAG, Mark
PATCH, Raymond, J.
ZHANG, Rui
CASE, Martin A.
WALL, Mark
ZHANG, Yue-Mei
Title: CYCLIC PEPTIDE TYROSINE TYROSINE COMPOUNDS AS MODULATORS OF NEUROPEPTIDE Y RECEPTORS
Abstract:
The present invention comprises compounds of Formula I wherein: Z4, Z7, Z9, Z11, Z22, Z23, Z26, Z30, Z34, Z35, p, m, n, q, and BRIDGE are defined in the specification. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel compounds are useful for preventing, treating or ameliorating diseases and disorders, such as obesity, type 2 diabetes, the metabolic syndrome, insulin resistance, and dyslipidemia, among others.