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1. (WO2018081309) DISULFIRAM AND METAL SALT STAGGERED ORAL DOSING REGIMEN AND STAGGERED-RELEASE ORAL UNIT DOSAGE FORMS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/081309 International Application No.: PCT/US2017/058358
Publication Date: 03.05.2018 International Filing Date: 25.10.2017
IPC:
A61K 31/105 (2006.01) ,A61K 31/16 (2006.01) ,A61K 31/27 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
095
Sulfur, selenium or tellurium compounds, e.g. thiols
105
Persulfides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
27
of carbamic or thiocarbamic acids, e.g. meprobamate, carbachol, neostigmine
Applicants: CANTEX PHARMACEUTICALS, INC.[US/US]; 1792 Bell Tower Lane Weston, FL 33326, US
Inventors: MARCUS, Stephen; US
Agent: RODRIGUEZ, Elena, M.; US
BECKER, Daniel, M.; US
SEQUEIRA, Antonia, L.; US
SHUSTER, Michael, J.; US
Priority Data:
62/413,25726.10.2016US
62/451,59727.01.2017US
62/550,50025.08.2017US
Title (EN) DISULFIRAM AND METAL SALT STAGGERED ORAL DOSING REGIMEN AND STAGGERED-RELEASE ORAL UNIT DOSAGE FORMS
(FR) SCHÉMA POSOLOGIQUE ORAL EN QUINCONCE À BASE DE DISULFIRAME ET DE SEL MÉTALLIQUE ET FORMES POSOLOGIQUES D'UNITÉ ORALE À LIBÉRATION ÉCHELONNÉE
Abstract:
(EN) This application relates to methods and compositions for the administration of disulfiram (DSF) and heavy metals zinc and copper for the treatment and prevention of medical conditions, such as cancer. DSF and copper as well as DSF and zinc form active complexes that have been shown to be effective in the treatment of cancers. However, as described herein, DSF is incompatible with either copper or zinc for simultaneous oral administration. Included herein are improved methods and oral dosage forms comprising DSF and copper and DSF and zinc in fixed dose combinations that are configured to temporally stagger release of either DSF and copper or DSF and zinc after ingestion.
(FR) La présente invention concerne des procédés et des compositions pour l'administration de disulfirame (DSF) et de métaux lourds de zinc et de cuivre pour le traitement et la prévention d'états médicaux, tels que le cancer. DSF et cuivre ainsi que DSF et zinc forment des complexes actifs qui ont été montrés être efficaces dans le traitement de cancers. Cependant, comme décrit dans la présente invention, DSF est incompatible soit avec le cuivre ou avec le zinc pour une administration orale simultanée. L'invention concerne également des procédés améliorés et des formes posologiques orales comprenant du DSF et du cuivre et du DSF et du zinc dans des combinaisons de doses fixes qui sont configurées pour une libération échelonnée temporaire de DSF et de cuivre ou de DSF et de zinc après ingestion.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)