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1. (WO2018081294) PYRAZOLE AMIDE COMPOUNDS AS IRAK INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/081294 International Application No.: PCT/US2017/058329
Publication Date: 03.05.2018 International Filing Date: 25.10.2017
IPC:
C07D 401/14 (2006.01) ,C07D 405/14 (2006.01) ,C07D 413/14 (2006.01) ,C07D 471/04 (2006.01) ,A61K 31/44 (2006.01) ,A61K 31/4439 (2006.01) ,A61K 31/497 (2006.01) ,A61P 35/00 (2006.01) ,A61P 37/00 (2006.01) ,A61P 25/00 (2006.01) ,A61P 9/00 (2006.01) ,A61P 7/00 (2006.01) ,A61P 1/00 (2006.01) ,A61P 3/00 (2006.01) ,A61P 11/00 (2006.01)
Applicants: RIGEL PHARMACEUTICALS, INC.[US/US]; 1180 Veterans Boulevard South San Francisco, CA 94080, US
Inventors: TSO, Kin; US
LI, Hui; US
CHEN, Yan; US
YEN, Rose; US
TAYLOR, Vanessa; US
HECKRODT, Thilo; US
SINGH, Rajinder; US
SHAW, Simon; US
Agent: SLATER, Stacey, C.; US
Priority Data:
62/413,29926.10.2016US
Title (EN) PYRAZOLE AMIDE COMPOUNDS AS IRAK INHIBITORS
(FR) COMPOSÉS PYRAZOLE AMIDE EN TANT QU'INHIBITEURS D'IRAK
Abstract: front page image
(EN) Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors of formula 1 and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/ or compositions may be used to treat or prevent an IRAK-associated disease or condition.
(FR) Les formes de réalisation de l'invention se rapportent à de nouveaux inhibiteurs de kinases associées au récepteur de l'interleukine (IRAK) de formule (1) et à des compositions comprenant de tels inhibiteurs. L'invention concerne également des procédés de fabrication et d'utilisation des composés et des compositions. Les composés et/ou compositions selon l'invention peuvent être utilisés pour traiter ou prévenir une maladie ou un état associé aux IRAK.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)