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1. (WO2018081289) PREFUSION PIV F IMMUNOGENS AND THEIR USE

Pub. No.:    WO/2018/081289    International Application No.:    PCT/US2017/058322
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Thu Oct 26 01:59:59 CEST 2017
IPC: A61K 39/12
A61P 31/14
Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
INSTITUTE FOR RESEARCH IN BIOMEDICINE
Inventors: ZHANG, Baoshan
TSYBOVSKY, Yaroslav
XU, Kai
KWONG, Peter
ZHOU, Tongqing
CHUANG, Gwo-Yu
CORTI, Davide
YANG, Yongping
KONG, Wing-Pui
MASCOLA, John
DRUZ, Aliaksandr
STEWART-JONES, Guillaume
OU, Li
THOMAS, Paul
LANZAVECCHIA, Antonio
Title: PREFUSION PIV F IMMUNOGENS AND THEIR USE
Abstract:
Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.