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1. (WO2018081285) UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/081285    International Application No.:    PCT/US2017/058314
Publication Date: 03.05.2018 International Filing Date: 25.10.2017
IPC:
A61K 31/422 (2006.01), C07D 261/08 (2006.01), C07D 413/12 (2006.01)
Applicants: ENANTA PHARMACEUTICALS, INC. [US/US]; 500 Arsenal Street Watertown, MA 02472 (US)
Inventors: HE, Jing; (US).
WANG, Guoqiang; (US).
SHEN, Ruichao; (US).
XING, Xuechao; (US).
WANG, Bin; (US).
MA, Jun; (US).
OR, Yat, Sun; (US)
Agent: HARLAN, Edgar W.; (US).
HARLAN, Edgar, W.; (US)
Priority Data:
62/413,372 26.10.2016 US
Title (EN) UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF
(FR) DÉRIVÉS D'ISOXAZOLE CONTENANT DE L'URÉE UTILISÉS COMME AGONISTES DE FXR ET LEURS PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)The present invention provides compounds of Formula (I), Pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR- mediated or TGR5-mediated diseases or conditions.
(FR)La présente invention concerne des composés de formule (I), des sels pharmaceutiquement acceptables de ceux-ci, des compositions pharmaceutiques comprenant ces composés et des procédés d'utilisation de ces composés pour prévenir ou traiter des maladies ou états pathologiques médiés par FXR ou par TGR5.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)