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1. (WO2018081130) METHODS AND SYSTEMS FOR TUMOR DETECTION
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Pub. No.: WO/2018/081130 International Application No.: PCT/US2017/058099
Publication Date: 03.05.2018 International Filing Date: 24.10.2017
IPC:
C12Q 1/68 (2018.01) ,G01N 33/574 (2006.01) ,G06F 19/18 (2011.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
F
ELECTRIC DIGITAL DATA PROCESSING
19
Digital computing or data processing equipment or methods, specially adapted for specific applications
10
Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology
18
for functional genomics or proteomics, e.g. genotype-phenotype associations, linkage disequilibrium, population genetics, binding site identification, mutagenesis, genotyping or genome annotation, protein-protein interactions or protein-nucleic acid interactions
Applicants:
THE CHINESE UNIVERSITY OF HONG KONG [CN/CN]; Room 301, Pi Ch'iu Building Shatin, New Territories Hong Kong, CN
GRAIL, INC. [US/US]; US
Inventors:
NAMSARAEV, Eugeni; US
LO, Yuk-Ming Dennis; CN
CHUI, Rossa Wai Kwun; CN
CHAN, Kwan Chee; CN
JIANG, Peiyong; CN
SUN, Kun; CN
LAM, Wai Kei; CN
Agent:
HARIHARAN, Venkatesh; US
SEIDEL, Jeffrey; US
Priority Data:
62/411,92924.10.2016US
62/450,54125.01.2017US
62/507,15416.05.2017US
Title (EN) METHODS AND SYSTEMS FOR TUMOR DETECTION
(FR) MÉTHODES ET SYSTÈMES DE DÉTECTION D'UNE TUMEUR
Abstract:
(EN) Methods are provided to improve the positive predictive value for cancer detection using cell-free nucleic acid samples. Various embodiments are directed to applications (e.g., diagnostic applications) of the analysis of the fragmentation patterns and size of cell-free DNA, e.g., plasma DNA and serum DNA, including nucleic acids from pathogens, including viruses. Embodiments of one application can determine if a subject has a particular condition. For example, a method of present disclosure can determine if a subject has cancer or a tumor, or other pathology. Embodiments of another application can be used to assess the stage of a condition, or the progression of a condition over time. For example, a method of the present disclosure may be used to determine a stage of cancer in a subject, or the progression of cancer in a subject over time (e.g., using samples obtained from a subject at different times).
(FR) La présente divulgation concerne des méthodes destinées à améliorer la valeur prédictive positive en matière de dépistage du cancer à l'aide d'échantillons d'acides nucléiques acellulaires. Divers modes de réalisation concernent des applications (p. ex., applications diagnostiques) de type analyse des motifs de fragmentation et de la taille de l'ADN acellulaire, p. ex., ADN plasmatique et ADN sérique, comprenant des acides nucléiques provenant d'agents pathogènes, y compris de virus. Des modes de réalisation d'une application permettent de déterminer si un sujet présente un état pathologique particulier. Par exemple, une méthode selon la présente divulgation peut déterminer si un sujet présente un cancer, une tumeur, ou autre pathologie. Des modes de réalisation d'une autre application peuvent être utilisés pour évaluer le stade d'un état pathologique, ou l'évolution d'un état pathologique dans le temps. Par exemple, une méthode selon la présente divulgation peut être utilisée pour déterminer le stade du cancer chez un sujet, ou l'évolution du cancer chez un sujet dans le temps (p. ex., à l'aide d'échantillons prélevés sur le sujet à différents moments).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)