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1. (WO2018081085) METHODS OF DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE
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Pub. No.: WO/2018/081085 International Application No.: PCT/US2017/058039
Publication Date: 03.05.2018 International Filing Date: 24.10.2017
IPC:
A61K 39/00 (2006.01) ,A61K 38/00 (2006.01)
[IPC code unknown for A61K 39][IPC code unknown for A61K 38]
Applicants:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street 12th Floor Oakland, California 94607-5200, US
Inventors:
ZHAN, Xinhua; US
STAMOVA, Boryana; US
SHARP, Frank; US
Agent:
HAO, Joe C.; US
Priority Data:
62/412,68425.10.2016US
Title (EN) METHODS OF DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE
(FR) MÉTHODES DE DIAGNOSTIC ET DE TRAITEMENT DE LA MALADIE D'ALZHEIMER
Abstract:
(EN) Provided are methods of mitigating, reversing or eliminating in a subject one or more symptoms associated with cognitive impairment associated with amyloid deposits in the brain (e.g., olfactory dysfunction as a risk factor of dementia, mild cognitive impairment, Alzheimer's Disease) by detecting and targeting gram negative bacteria in the brain.
(FR) L'invention concerne des méthodes qui permettent d'atténuer, d'inverser ou d'éliminer, chez un sujet, un ou plusieurs symptômes associés à une déficience cognitive associée à des dépôts amyloïdes dans le cerveau (par exemple, un dysfonctionnement olfactif en tant que facteur de risque de démence, une déficience cognitive légère, la maladie d'Alzheimer) par détection et ciblage de bactéries à gram négatif dans le cerveau.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)