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1. (WO2018080990) ENHANCEMENT OF MSC IMMUNOMODULATORY PROPERTIES BY TREPROSTINIL
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/080990 International Application No.: PCT/US2017/057863
Publication Date: 03.05.2018 International Filing Date: 23.10.2017
IPC:
A61K 35/28 (2015.01) ,C12N 5/0789 (2010.01) ,A61P 9/00 (2006.01) ,A61P 9/10 (2006.01) ,A61P 11/00 (2006.01)
Applicants: UNITED THERAPEUTICS CORPORATION[US/US]; 1040 Spring Street Silver Spring, Maryland 20910, US
Inventors: ILAGAN, Roger Marquez; US
HOGAN, Sarah; US
CHEADLE, John B.; US
Agent: MAEBIUS, Stephen B.; US
RAWLINS, Andrew E.; US
LAW, Glenn; US
AGARWAL, Pavan K.; US
BECK, George C.; US
BERKOWITZ, Benjamin A.; US
BRINCKERHOFF, Courtenay C.; US
CHESLOCK, Andrew R.; US
FELDHAUS, John J.; US
KAMINSKI, Michael D.; US
QUILLIN, George E.; US
SCHORR, Kristel; US
SIMKIN, Michele M.; US
TALAPATRA, Sunit; US
VILLACORTA, Gilberto M.; US
YAN, Tianran; US
Priority Data:
62/411,95024.10.2016US
Title (EN) ENHANCEMENT OF MSC IMMUNOMODULATORY PROPERTIES BY TREPROSTINIL
(FR) AMÉLIORATION DE PROPRIÉTÉS IMMUNOMODULATRICES DES CSM PAR LE TRÉPROSTINIL
Abstract: front page image
(EN) Provided are methods for treating or preventing vasculopathy comprising administering to a subject in need thereof, ac composition comprising a mesenchymal stem cell (MSC), or a part of a culture medium that has been in contact with the MSC and comprises one or more components of the MSC, or an exosome derived from the MSC. Pharmaceutical compositions suitable for such treatment is also provided.
(FR) La présente invention concerne des méthodes de traitement prophylactique ou thérapeutique des vasculopathies comprenant l'administration à un sujet le nécessitant d'une composition comprenant une cellule souche mésenchymateuse (CSM), ou une partie d'un milieu de culture ayant été en contact avec la CSM et comprenant un ou plusieurs composants de la CSM, ou un exosome dérivé de la CSM. L'invention concerne également des compositions pharmaceutiques adaptées à un tel traitement.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)