A blended sweetener mixture that includes multiple high-intensity sweeteners, optionally combined with one or more bulk sweeteners such as sugar. Combining multiple high-intensity sweeteners creates synergistic effects on taste, while limiting the toxicity from any one ingredient. Mixtures of three or more high-intensity sweeteners may limit the sweetness contribution of any single ingredient to no more than 80% of the total sweetness of the mixture, and limit the sweetness contribution of any two ingredients to no more than 90% of the total sweetness of the mixture. Illustrative high-intensity sweeteners used in embodiments may include for example stevia, sucralose, neotame, and acesulfame potassium; illustrative bulk sweeteners may include for example bulk sugar, bulk powdered or agglomerated sugar, and bulk erythritol. Combinations of multiple high-intensity sweeteners and bulk sweeteners may for example provide effective sugar substitutes with equivalent or greater sweetness, lower calories, and lower glycemic loads.