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1. (WO2018080889) A VIRUS LIKE PARTICLE OF HEPATITIS B VIRUS PRE-S PROTEIN
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Pub. No.: WO/2018/080889 International Application No.: PCT/US2017/057390
Publication Date: 03.05.2018 International Filing Date: 19.10.2017
IPC:
A61K 38/00 (2006.01) ,A61K 39/00 (2006.01) ,A61K 39/29 (2006.01) ,A61P 31/12 (2006.01) ,A61P 43/00 (2006.01) ,C12N 5/10 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
29
Hepatitis virus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
Applicants:
GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. [US/US]; 30 Courtland Street Atlanta, Georgia 30303, US
Inventors:
LUO, Ming; US
Agent:
GILES, Brian, P.; US
Priority Data:
62/414,89931.10.2016US
Title (EN) A VIRUS LIKE PARTICLE OF HEPATITIS B VIRUS PRE-S PROTEIN
(FR) PARTICULE PSEUDO-VIRALE DE LA PROTÉINE PRÉ-S DU VIRUS DE L'HÉPATITE B
Abstract:
(EN) As disclosed herein, the preS antigen on infectious hepatitis B virus (HBV) particles can provide B and T ceil epitopes that promote the humoral and cellular responses and enhance the seroprotection rate by overcoming non-responsiveness to the S antigen-only vaccines. Therefore, compositions and methods are disclosed using the preS antigen to develop vaccines and immune therapies for treating or preventing hepatitis B infection, in particular, virus-like particles (VLPs) are disclosed that contain the preS antigen on its surface. These VLPs can be used alone or in combination with vaccines containing the hepatitis B surface antigen (HBsAg) to vaccinate subjects against HBV as well as to activate T ceils for adoptive T cell therapy to eradicate HBV infected hapatocytes.
(FR) Comme le décrit l'invention, l'antigène préS sur les particules du virus infectieux de l'hépatite B (VHB) peut fournir des épitopes de lymphocytes B et T qui favorisent les réponses humorales et cellulaires et améliorent le niveau de séroprotection en surmontant la non-réactivité aux vaccins contenant uniquement l'antigène S. Par conséquent, l'invention concerne des compositions et des procédés utilisant l'antigène préS pour développer des vaccins et des thérapies immunitaires afin de traiter ou de prévenir une infection par l'hépatite B, en particulier l'invention concerne des particules pseudo-virales (VLP) qui contiennent l'antigène préS sur leur surface. Ces VLP peuvent être utilisées seules ou en combinaison avec des vaccins contenant l'antigène de surface de l'hépatite B (HBsAg) pour vacciner des patients contre le VHB, ainsi que pour activer les lymphocytes T à des fins de thérapie adoptive par lymphocytes T afin d'éradiquer les hépatocytes infectés par le VHB.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)