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1. (WO2018080521) PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/080521 International Application No.: PCT/US2016/059544
Publication Date: 03.05.2018 International Filing Date: 28.10.2016
IPC:
A61K 9/00 (2006.01) ,A61K 9/16 (2006.01) ,A61K 9/19 (2006.01)
Applicants: SPINETHERA[US/US]; 15600 Medina Road Suite 247 Plymouth, Minnesota 55447, US
Inventors: MISSLING, Jeffrey; US
ROLFES MEYERING, Emily R.; US
MEYER, Henry; US
ONDICH, Celeste; US
Agent: PERDOK, Monique M.; US
SCHEER, Bradley W., Reg. No. 47,059; US
BLACK, David W., Reg. No. 42,331; US
BIANCHI, Timothy E., Reg. No. 39,610; US
ARORA, Suneel, Reg. No. 42,267; US
WOO, Justin N., Reg. No. 62,686; US
GOULD, James R., Reg. No. 72,086; US
MCCRACKIN, Ann M., Reg. No. 42,858; US
BEEKMAN, Marvin, Reg. No. 38,377; US
Priority Data:
Title (EN) PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
(FR) COMPOSITIONS PHARMACEUTIQUES ET UTILISATIONS CORRESPONDANTES
Abstract: front page image
(EN) Embodiments of the present invention are directed to a plurality of substantially spherical microspheres comprising at least one API substantially dispersed in at least one polymer and a lyoprotectant on an outside surface of the plurality of substantially spherical microspheres, wherein the plurality of substantially spherical microspheres have a D99[num] particle diameter of less than about 10 m; a D90[num] circularity value of from about 0.8 to about 1.0; and comprise API in a weight of about 20 to about 40 wt.% of the polymer. Other embodiments relate to injectable compositions comprising such microspheres and methods of treating a number of conditions by administering such injectable compositions to a subject.
(FR) Des modes de réalisation de la présente invention concernent de multiples microsphères sensiblement sphériques comprenant au moins un principe actif (API) largement dispersé dans au moins un polymère, ainsi qu'un lyoprotecteur présent sur la surface extérieure des multiples microsphères sensiblement sphériques, les multiples microsphères sensiblement sphériques ayant un diamètre particulaire D99[num] inférieur à environ 10 m ; une valeur de circularité D90[num] comprise entre environ 0,8 et environ 1,0 ; et comprenant un API dont la valeur en poids est comprise entre environ 20 et environ 40 % du poids du polymère. D'autres modes de réalisation concernent des compositions injectables comprenant de telles microsphères et des méthodes de traitement d'un certain nombre de pathologies par administration de telles compositions injectables à un patient.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)