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1. (WO2018080306) MOLECULAR INDICATORS FOR PREDICTING RESPONSE TO HORMONAL THERAPY IN BREAST CANCER
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Pub. No.: WO/2018/080306 International Application No.: PCT/NL2017/050698
Publication Date: 03.05.2018 International Filing Date: 25.10.2017
IPC:
C07K 16/18 (2006.01) ,C12Q 1/68 ,G01N 33/574 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
Applicants:
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS [NL/NL]; Plesmanlaan 121 1066 CX Amsterdam, NL
STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN; NL
Inventors:
ZWART, Willem Teunis; NL
NEVEDOMSKAYA, Ekaterina; NL
WESSELS, Lodewijk Frederik Ary; NL
Agent:
ALGEMEEN OCTROOI- EN MERKENBUREAU B.V.; P.O. Box 645 5600 AP Eindhoven, NL
Priority Data:
201767025.10.2016NL
Title (EN) MOLECULAR INDICATORS FOR PREDICTING RESPONSE TO HORMONAL THERAPY IN BREAST CANCER
(FR) INDICATEURS MOLÉCULAIRES POUR PRÉDIRE UNE RÉACTIVITÉ À UNE THÉRAPIE HORMONALE DANS LE CANCER DU SEIN
Abstract:
(EN) The invention provides for a method for predicting responsiveness, i.e. sensitivity or resistance, of an estrogen receptor a-positive tumor to hormonal therapy based upon predictive biomarkers. The invention will aid in determining a suitable therapy for ERa-positive cancer patients. Kits and arrays for predicting responsiveness of an ERa-positive tumor to hormonal therapy are also provided. Finally, the invention provides for use of hormonal therapy or chemotherapy in a select patient group, i.e., those identified based on predicted response to hormonal therapy.
(FR) L'invention concerne un procédé de prédiction de la réactivité, c'est-à-dire la sensibilité ou la résistance, d'une tumeur a-positive au récepteur des œstrogènes à une thérapie hormonale sur la base de biomarqueurs prédictifs. L'invention aide à déterminer une thérapie appropriée pour des patients atteints d'un cancer positif à l'ERa. L'invention concerne également des kits et des jeux ordonnés d'échantillons pour la prédiction de la réactivité d'une tumeur ERa-positive à une thérapie hormonale. Enfin, l'invention concerne l'utilisation d'une thérapie hormonale ou d'une chimiothérapie dans un groupe de patients sélectionnés, c'est-à-dire ceux identifiés sur la base d'une réactivité prédite à une thérapie hormonale.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)