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1. (WO2018080252) IMMUNE RESPONSE REGULATORY SUBSTANCE AND VACCINE COMPOSITION CONTAINING SAME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/080252    International Application No.:    PCT/KR2017/012050
Publication Date: 03.05.2018 International Filing Date: 30.10.2017
IPC:
A61K 39/12 (2006.01), A61K 39/295 (2006.01), A61K 39/39 (2006.01), A61K 39/002 (2006.01), A61K 39/00 (2006.01)
Applicants: EYEGENE INC. [KR/KR]; B-901 401, Yangcheon-ro Gangseo-gu Seoul 07528 (KR)
Inventors: CHO, Yang Je; (KR).
KIM, Kwangsung; (KR).
LEE, Na Gyong; (KR).
PARK, Shin Ae; (KR)
Agent: LEE, Cheo Young; (KR).
CHANG, Je Hwan; (KR)
Priority Data:
10-2016-0142703 31.10.2016 KR
10-2017-0079762 23.06.2017 KR
Title (EN) IMMUNE RESPONSE REGULATORY SUBSTANCE AND VACCINE COMPOSITION CONTAINING SAME
(FR) SUBSTANCE RÉGULATRICE DE LA RÉPONSE IMMUNITAIRE ET COMPOSITION VACCINALE LA CONTENANT
(KO) 면역반응 조절물질 및 이를 포함하는 백신 조성물
Abstract: front page image
(EN)The present invention relates to an immune response regulatory substance having a novel structure, and an immunologic adjuvant composition containing the same and, more specifically, to an immune response regulatory substance, which is a lipopolysaccharide (LPS) analog having reduced toxicity, and a use thereof. The immune response regulatory substance of the present invention exhibits immune enhancement effects by having excellent innate immunity and ability to induce an adaptive immune response to a specific pathogen, and is very safe by having lox toxicity. In addition, a vaccine containing the immune response regulatory substance of the present invention contains both an immune response regulatory substance and an alum, thereby improving immune enhancement effects compared with when using only the immune response regulatory substance.
(FR)La présente invention concerne une substance régulatrice de la réponse immunitaire possédant une structure nouvelle, et une composition à rôle d'adjuvant de la réponse immunitaire la contenant et, plus spécifiquement, une substance régulatrice de la réponse immunitaire qui est un analogue du lipopolysaccharide (LPS) présentant une moindre toxicité, ainsi qu'une utilisation de cette dernière. La substance régulatrice de la réponse immunitaire de la présente invention présente des effets de stimulation de la réponse immunitaire grâce son excellente action de type immunité innée et grâce à une excellente aptitude à induire une réponse immunitaire adaptative à un pathogène spécifique, et est très sûre d'emploi du fait de sa faible toxicité. De plus, un vaccin contenant la substance régulatrice de la réponse immunitaire de la présente invention contient à la fois une substance régulatrice de la réponse immunitaire et un alun, permettant ainsi d'améliorer les effets de stimulation de la réponse immunitaire en comparaison avec l'utilisation de la substance régulatrice de la réponse immunitaire seule.
(KO)본 발명은 신규한 구조의 면역반응 조절물질 및 이를 포함하는 면역보조제 조성물에 관한 것으로, 더욱 상세하게는, 독성을 감소시킨 리포폴리사카라이드(lipopolysaccharide; LPS) 유사체인 면역반응 조절물질 및 이의 용도에 관한 것이다. 본 발명의 면역반응 조절물질은 내재면역 및 특정 병원체에 대한 적응면역반응 유도능이 우수해 면역증강효능을 발휘할 뿐만 아니라 독성이 거의 없어 안전성이 매우 우수하다. 또한 본 발명의 면역반응 조절물질을 포함하는 백신은 면역반응 조절물질과 알룸(alum)을 모두 포함함으로써, 면역반응 조절물질을 단독으로 사용하는 경우에 비해 향상된 면역증강효능을 발휘한다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)