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1. (WO2018080155) METHOD FOR PRODUCING POLYMER COATING-BASED NITROGEN OXIDE DELIVERY COMPOSITE, AND USE OF SAME
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Pub. No.:    WO/2018/080155    International Application No.:    PCT/KR2017/011814
Publication Date: 03.05.2018 International Filing Date: 25.10.2017
IPC:
A61K 9/51 (2006.01), A61K 9/70 (2006.01), A61K 33/00 (2006.01), C08J 3/12 (2006.01), C08K 3/36 (2006.01)
Applicants: CHUNG-ANG UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR/KR]; 84, Heukseok-ro, Dongjak-gu, Seoul 06974 (KR)
Inventors: HONG, Jinkee; (KR).
JEONG, Hye Joong; (KR)
Agent: DANA PATENT LAW FIRM; 5th Floor, New Wing, Gwangsung Bldg., 11, Yeoksam-ro 3-gil, Gangnam-gu, Seoul 06242 (KR)
Priority Data:
10-2016-0142007 28.10.2016 KR
Title (EN) METHOD FOR PRODUCING POLYMER COATING-BASED NITROGEN OXIDE DELIVERY COMPOSITE, AND USE OF SAME
(FR) PROCÉDÉ POUR LA PRODUCTION D'UN COMPOSITE D'ADMINISTRATION D'OXYDE D'AZOTE À BASE DE REVÊTEMENT POLYMÈRE, ET SON UTILISATION
(KO) 고분자 코팅 기반의 산화질소 전달용 복합체 제작 방법 및 이의 응용
Abstract: front page image
(EN)The present invention relates to a nitrogen oxide delivery composite in which the surface of a base material such as nano-particles or the like is modified by a polymer having a secondary amine group. A secondary amine forms a diazeniumdiolate functional group through a high pressure reaction with nitrogen monoxide, and the functional group can function as a nitrogen oxide provider. According to the present invention, the surface of a base material can be modified by a polymer to be single layer or multilayer through a layer-by-layer (LbL) coating method. The production technique involves simple processes, is economical, and can be applied in a wide range of fields. In addition, the emission speed and emission amount of nitrogen monoxide can be easily adjusted, and the distribution of a base material such as nano-particles or the like can be increased. The nitrogen oxide delivery composite produced according to the present invention is not cytotoxic, and thus is expected to be usable for medical purposes, such as for enlarging blood vessels, treating wounds, or killing bacteria and the like, in vivo, through adjustment of the emission amount and emission speed of nitrogen monoxide.
(FR)La présente invention concerne un composite d'administration d'oxyde d'azote dans lequel la surface d'un matériau de base tel que des nanoparticules ou analogues est modifiée par un polymère ayant un groupe amine secondaire. Une amine secondaire forme un groupe fonctionnel diazéniumdiolate par une réaction haute pression avec du monoxyde d'azote, et le groupe fonctionnel peut fonctionner en tant que fournisseur d'oxyde d'azote. Selon la présente invention, la surface d'un matériau de base peut être modifiée par un polymère pour être monocouche ou multicouche grâce à un procédé de revêtement de couche par couche (LbL). La technique de production comprend des processus simples, est économique, et peut être appliquée dans une large gamme de domaines. En outre, la vitesse d'émission et la quantité d'émission de monoxyde d'azote peuvent être facilement ajustées, et la distribution d'un matériau de base tel que des nanoparticules ou analogues peut être augmentée. Le composite d'administration d'oxyde d'azote produit selon la présente invention n'est pas cytotoxique, et est donc prévu pour être utilisable à des fins médicales, par exemple pour élargir des vaisseaux sanguins, traiter des plaies, ou éliminer des bactéries et analogues, in vivo, par ajustement de la quantité d'émission et de la vitesse d'émission du monoxyde d'azote.
(KO)본 발명은 이차 아민(secondary amine) 그룹을 가지는 고분자로 나노 입자 등의 기재의 표면을 개질한 산화질소 전달용 복합체에 관한 것이다. 이차 아민은 일산화질소와의 고압 반응을 통해서 다이아제니움다이올레이트(Diazeniumdiolate) 작용기를 형성하며, 상기 작용기는 산화질소 제공자로 작용할 수 있다. 본 발명에서는 층과층(LbL) 코팅법을 통해서 고분자로 기재 표면을 단층 혹은 다층으로 개질 가능하다. 상기 제조 기술은 공정이 간단하고 경제적이며 응용 분야가 넓다. 또한 일산화질소의 방출 속도 및 방출량의 조절이 용이하며 나노 입자 등의 기재의 분포도를 증대시킬 수 있는 장점이 있다. 본 발명에 따라 제조된 산화질소 전달용 복합체는 세포 독성이 없으므로, 일산화질소의 방출량 및 방출 속도의 조절을 통해 체내에서 혈관확장, 상처치유, 항균 등의 의료용 목적으로 활용할 수 있을 것으로 예상된다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)