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1. (WO2018080155) METHOD FOR PRODUCING POLYMER COATING-BASED NITROGEN OXIDE DELIVERY COMPOSITE, AND USE OF SAME

Pub. No.:    WO/2018/080155    International Application No.:    PCT/KR2017/011814
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Thu Oct 26 01:59:59 CEST 2017
IPC: A61K 9/51
A61K 9/70
A61K 33/00
C08J 3/12
C08K 3/36
Applicants: CHUNG-ANG UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
중앙대학교 산학협력단
Inventors: HONG, Jinkee
홍진기
JEONG, Hye Joong
정혜중
Title: METHOD FOR PRODUCING POLYMER COATING-BASED NITROGEN OXIDE DELIVERY COMPOSITE, AND USE OF SAME
Abstract:
The present invention relates to a nitrogen oxide delivery composite in which the surface of a base material such as nano-particles or the like is modified by a polymer having a secondary amine group. A secondary amine forms a diazeniumdiolate functional group through a high pressure reaction with nitrogen monoxide, and the functional group can function as a nitrogen oxide provider. According to the present invention, the surface of a base material can be modified by a polymer to be single layer or multilayer through a layer-by-layer (LbL) coating method. The production technique involves simple processes, is economical, and can be applied in a wide range of fields. In addition, the emission speed and emission amount of nitrogen monoxide can be easily adjusted, and the distribution of a base material such as nano-particles or the like can be increased. The nitrogen oxide delivery composite produced according to the present invention is not cytotoxic, and thus is expected to be usable for medical purposes, such as for enlarging blood vessels, treating wounds, or killing bacteria and the like, in vivo, through adjustment of the emission amount and emission speed of nitrogen monoxide.