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1. (WO2018080146) COMPOSITION COMPRISING PROTEIN PHOSPHATASE 1 INHIBITORY PEPTIDE FOR TREATING VASCULAR DISEASES

Pub. No.:    WO/2018/080146    International Application No.:    PCT/KR2017/011796
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Wed Oct 25 01:59:59 CEST 2017
IPC: A61K 38/08
A23L 33/18
Applicants: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY
광주과학기술원
Inventors: PARK, Woo Jin
박우진
JANG, Seung Pil
장승필
Title: COMPOSITION COMPRISING PROTEIN PHOSPHATASE 1 INHIBITORY PEPTIDE FOR TREATING VASCULAR DISEASES
Abstract:
The present invention relates to a composition comprising a protein phosphatase 1 inhibitory peptide for treating vascular diseases. The composition of the present invention inhibits protein phosphatase 1 (PP1)-mediated dephosphorylation to suppress abnormal proliferation of vascular smooth muscle cells (VSMCs), and activates eNOS of vascular endothelial cells (VECs) to induce the recovery from dysfunction, and thus can be favorably used in the treatment of vascular diseases including pulmonary hypertension.