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1. (WO2018079988) COMPOUND USEFUL AS TRAP1 INHIBITOR, AND ANTICANCER COMPOSITION CONTAINING SAME
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Pub. No.: WO/2018/079988 International Application No.: PCT/KR2017/007907
Publication Date: 03.05.2018 International Filing Date: 21.07.2017
IPC:
A61K 31/519 (2006.01) ,A61K 31/36 (2006.01) ,C07D 487/04 (2006.01) ,C07D 317/46 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
357
having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
36
Compounds containing methylenedioxyphenyl groups, e.g. sesamin
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
317
Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
08
having the hetero atoms in positions 1 and 3
44
ortho- or peri-condensed with carbocyclic rings or ring systems
46
condensed with one six-membered ring
Applicants:
울산과학기술원 UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY) [KR/KR]; 울산시 울주군 언양읍 유니스트길 50 50, UNIST-gil Eonyang-eup Ulju-gun Ulsan 44919, KR
Inventors:
강병헌 KANG, Byoung Heon; KR
박혜경 PARK, Hye Kyung; KR
이창욱 LEE, Changwook; KR
강수성 KANG, Soosung; KR
이지훈 LEE, Ji Hoon; KR
홍기범 HONG, Ki-Bum; KR
김다롱 KIM, Darong; KR
이원석 LEE, Won Seok; KR
고은화 KO, Eunhwa; KR
이상광 LEE, Sang Kwang; KR
김성헌 KIM, Seong Heon; KR
이금우 LEE, Geum Woo; KR
Agent:
유미특허법인 YOU ME PATENT AND LAW FIRM; 서울시 강남구 테헤란로 115 115 Teheran-ro, Gangnam-gu, Seoul 06134, KR
Priority Data:
10-2016-014026026.10.2016KR
Title (EN) COMPOUND USEFUL AS TRAP1 INHIBITOR, AND ANTICANCER COMPOSITION CONTAINING SAME
(FR) COMPOSÉ UTILE EN TANT QU'INHIBITEUR DE TRAP1, ET COMPOSITION ANTICANCÉREUSE LE CONTENANT
(KO) TRAP1 저해제로서 유용한 화합물 및 이를 포함하는 항암용 조성물
Abstract:
(EN) The present invention relates to a compound simultaneously inhibiting a heat shock protein Hsp90 and a Hsp90 homologous protein such as TRAP1 and, more specifically, to: a compound having a structure of the following chemical formula I, and being useful as an inhibitor of Hsp90 and a homologous protein thereof; and an anticancer composition containing the same.
(FR) La présente invention concerne un composé inhibant simultanément une protéine de choc thermique Hsp90 et une protéine homologue Hsp90 telle que TRAP1 et, plus spécifiquement: un composé qui a une structure de formule chimique I suivante, et qui est utile en tant qu'inhibiteur de Hsp90 et d'une protéine homologue de celle-ci; et une composition anticancéreuse contenant ledit composé.
(KO) 본 발명은 열 충격 단백질 (heat shock protein) Hsp90및 TRAP1과 같은 Hsp90 상동단백질을 동시에 저해하는 화합물에 관한 것으로서, 보다 상세하게는 하기 화학식 I의 구조를 갖는 Hsp90 및 이의 상동단백질 저해제로서 유용한 화합물 및 이를 포함하는 항암용 조성물에 관한 것이다:
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)