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1. (WO2018079629) NOVEL PYRIMIDINE DERIVATIVE HAVING ANTIMALARIAL ACTIVITY

Pub. No.:    WO/2018/079629    International Application No.:    PCT/JP2017/038588
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Thu Oct 26 01:59:59 CEST 2017
IPC: C07D 471/04
A61K 31/506
A61K 31/5377
A61P 33/06
C07D 491/056
C07D 491/107
Applicants: CARNA BIOSCIENCES, INC.
カルナバイオサイエンス株式会社
THE KITASATO INSTITUTE
学校法人北里研究所
Inventors: SAWA, Masaaki
澤 匡明
ASAMITSU, Yuko
朝光 優子
UNO, Yuko
宇野 佑子
OMURA, Satoshi
大村 智
OTOGURO, Kazuhiko
乙黒 一彦
IWATSUKI, Masato
岩月 正人
ISHIYAMA, Aki
石山 亜紀
HOKARI, Rei
穗苅 玲
Title: NOVEL PYRIMIDINE DERIVATIVE HAVING ANTIMALARIAL ACTIVITY
Abstract:
The present invention provides a novel 2,4,6-substituted pyrimidine derivative, which is a compound represented by formula (I) (in the formula, ring A is a 6-membered heteroaryl group having at least one N atom optionally substituted with R1, R2, and R3; Z is an optionally substituted alkoxy group, an optionally substituted amino group, an optionally substituted heterocycloalkyl group, or an optionally substituted heteroaryl group; and R1, R2, and R3 are each independently selected from the group consisting of a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted alkoxy group, an optionally substituted cycloalkyloxy group, an optionally substituted heterocycloalkyloxy group, an optionally substituted phenoxy group, an optionally substituted amino group, a nitro group, and a hydroxy group) or a pharmaceutically acceptable salt thereof.