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1. (WO2018079628) PYRROLE DERIVATIVE WITH FUSED RING AND PHARMACEUTICAL USE THEREOF

Pub. No.:    WO/2018/079628    International Application No.:    PCT/JP2017/038584
Publication Date: Fri May 04 01:59:59 CEST 2018 International Filing Date: Thu Oct 26 01:59:59 CEST 2017
IPC: C07D 487/04
A61K 31/4985
A61P 3/04
A61P 25/00
A61P 25/04
A61P 25/08
A61P 25/18
A61P 25/20
A61P 25/22
A61P 25/24
A61P 25/28
A61P 25/36
A61P 43/00
Applicants: SUMITOMO DAINIPPON PHARMA CO., LTD.
大日本住友製薬株式会社
Inventors: TOJO, Kengo
東條 健剛
SHIMADA, Naoaki
島田 尚明
IKUMA, Yohei
井熊 洋平
KANEKO, Keiichi
金子 敬一
FUKUDA, Nobuhisa
福田 展久
Title: PYRROLE DERIVATIVE WITH FUSED RING AND PHARMACEUTICAL USE THEREOF
Abstract:
The present invention provides: a compound which is useful as a therapeutic agent for diseases associated with metabolic glutamic acid receptor subtype 2 (mGluR2), and which is represented by formula (1) [in formula (1), -X-ring B represents -C(O)-NRA-ring B or the like, ring A represents a C6-10 aromatic carbon ring or the like, ring B represents a 5- to 10-membered aromatic heterocycle or the like, R1 and R2 each represent a hydrogen atom, a C1-4 alkyl, or the like, R3 and R4 each represent a hydrogen atom, a halogen, or the like, R5, R6, and R7 each represent a hydrogen atom, a C1-6 alkyl, or the like, R8, R9, and R10 each represent a hydrogen atom, a C1-6 alkyl, or the like, and RA represents a hydrogen atom or the like] or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing the compound.