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1. (WO2018079393) DISULFIDE-TYPE HMGB1-SPECIFIC ANTIBODY, METHOD FOR MEASURING DISULFIDE-TYPE HMGB1 AND KIT FOR SAID MEASUREMENT, AND MEASUREMENT METHOD CAPABLE OF QUANTITATING ALL OF HMGB1 MOLECULES INCLUDING REDUCED HMGB1, DISULFIDE-TYPE HMGB1 AND THROMBIN-CLEAVABLE HMGB1 AND KIT FOR SAID MEASUREMENT
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Pub. No.: WO/2018/079393 International Application No.: PCT/JP2017/037789
Publication Date: 03.05.2018 International Filing Date: 19.10.2017
IPC:
C07K 16/18 (2006.01) ,C07K 16/46 (2006.01) ,C12P 21/08 (2006.01) ,G01N 33/53 (2006.01) ,C12N 15/09 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46
Hybrid immunoglobulins
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
08
Monoclonal antibodies
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
Applicants:
扶桑薬品工業株式会社 FUSO PHARMACEUTICAL INDUSTRIES, LTD. [JP/JP]; 大阪府大阪市中央区道修町1丁目7番10号 7-10, Dosho-machi 1-chome, Chuo-ku, Osaka-shi, Osaka 5410045, JP
Inventors:
朝倉 昌博 ASAKURA, Masahiro; JP
芥子 亜矢 KESHI, Aya; JP
安部 加奈子 ABE, Kanako; JP
坂本 奈々 SAKAMOTO, Nana; JP
山▲崎▼ 志保 YAMAZAKI, Shiho; JP
上原 啓嗣 UEHARA, Hirotsugu; JP
Agent:
春名 雅夫 HARUNA, Masao; JP
清水 初志 SHIMIZU, Hatsushi; JP
山口 裕孝 YAMAGUCHI, Hirotaka; JP
刑部 俊 OSAKABE, Suguru; JP
井上 隆一 INOUE, Ryuichi; JP
佐藤 利光 SATO, Toshimitsu; JP
新見 浩一 SHIMMI, Hirokazu; JP
小林 智彦 KOBAYASHI, Tomohiko; JP
小寺 秀紀 KODERA, Hideki; JP
大関 雅人 OHZEKI, Masato; JP
五十嵐 義弘 IGARASHI, Yoshihiro; JP
川本 和弥 KAWAMOTO, Kazuya; JP
Priority Data:
2016-20951026.10.2016JP
Title (EN) DISULFIDE-TYPE HMGB1-SPECIFIC ANTIBODY, METHOD FOR MEASURING DISULFIDE-TYPE HMGB1 AND KIT FOR SAID MEASUREMENT, AND MEASUREMENT METHOD CAPABLE OF QUANTITATING ALL OF HMGB1 MOLECULES INCLUDING REDUCED HMGB1, DISULFIDE-TYPE HMGB1 AND THROMBIN-CLEAVABLE HMGB1 AND KIT FOR SAID MEASUREMENT
(FR) ANTICORPS SPÉCIFIQUE DE HMGB1 DE TYPE DISULFURE, PROCÉDÉ DE MESURE DE HMGB1 DE TYPE DISULFURE ET KIT POUR LADITE MESURE, AINSI QU'UN PROCÉDÉ DE MESURE CAPABLE DE QUANTIFIER TOUTES LES MOLÉCULES DE HMGB1 COMPRENANT UNE HMGB1 RÉDUITE, UNE HMGB1 DE TYPE DISULFURE ET UNE HMGB1 POUVANT ÊTRE CLIVÉE PAR LA THROMBINE ET KIT POUR LADITE MESURE
(JA) ジスルフィド型HMGB1特異的抗体、ジスルフィド型HMGB1の測定方法および測定用キット、ならびに、還元型HMGB1、ジスルフィド型HMGB1、トロンビン分解HMGB1等の全てのHMGB1を定量することが可能な測定方法および測定用キット
Abstract:
(EN) Provided is an antibody capable of exhibiting a reaction specific to disulfide-type HMGB1. Also provided are: a method for specifically measuring disulfide-type HMGB1 with the antibody; and a kit or a reagent for the measurement. Also provided are: a method for measuring all of HMGB1 molecules with the antibody and an antibody capable of binding to both of disulfide-type HMGB1 and reduced HMGB1 and incapable of binding to des-HMGB1; and a kit or a reagent for the measurement.
(FR) L'invention concerne un anticorps capable de présenter une réaction spécifique à la HMGB1 de type disulfure. L'invention concerne également : un procédé de mesure spécifique de HMGB1 de type disulfure avec l'anticorps ; et un kit ou un réactif pour la mesure. L'invention concerne également : un procédé de mesure de toutes les molécules HMGB1 avec l'anticorps et un anticorps capable de se lier à la fois à HMGB1 de type disulfure et à HMGB1 réduite et incapable de se lier à des des-HMGB1 ; et un kit ou un réactif pour la mesure.
(JA) ジスルフィド型HMGB1に特異的な反応を示す抗体が提供された。また、当該抗体によるジスルフィド型HMGB1を特異的に測定する方法および測定用キットまたは試薬が提供された。さらに、当該抗体およびジスルフィド型HMGB1と還元型HMGB1の両方に結合しdes-HMGB1に結合しない抗体による全てのHMGB1の測定方法および測定用キットまたは試薬が提供された。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)