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1. (WO2018079287) MUTANT HUMAN DNA POLYMERASE ε
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Pub. No.: WO/2018/079287 International Application No.: PCT/JP2017/037039
Publication Date: 03.05.2018 International Filing Date: 12.10.2017
IPC:
C12N 15/09 (2006.01) ,C12N 9/10 (2006.01) ,C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10
Transferases (2.)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
デンカ株式会社 DENKA COMPANY LIMITED [JP/JP]; 東京都中央区日本橋室町二丁目1番1号 1-1, Nihonbashi-Muromachi 2-chome, Chuo-ku, Tokyo 1038338, JP
国立大学法人新潟大学 NIIGATA UNIVERSITY [JP/JP]; 新潟県新潟市西区五十嵐二の町8050番地 8050, Ikarashi 2-no-cho, Nishi-ku, Niigata-shi, Niigata 9502181, JP
Inventors:
井筒 浩 IZUTSU Hiroshi; JP
兒玉 啓輔 KODAMA Keisuke; JP
中田 光隆 NAKADA Mitsutaka; JP
若井 俊文 WAKAI Toshifumi; JP
亀山 仁史 KAMEYAMA Hitoshi; JP
永橋 昌幸 NAGAHASHI Masayuki; JP
島田 能史 SHIMADA Yoshifumi; JP
市川 寛 ICHIKAWA Hiroshi; JP
Agent:
長谷川 芳樹 HASEGAWA Yoshiki; JP
清水 義憲 SHIMIZU Yoshinori; JP
中塚 岳 NAKATSUKA Takeshi; JP
Priority Data:
2016-20968826.10.2016JP
Title (EN) MUTANT HUMAN DNA POLYMERASE ε
(FR) ADN POLYMÉRASE EPSILON HUMAINE MUTANTE
(JA) 変異型ヒトDNAポリメラーゼε
Abstract:
(EN) Provided is a mutant human DNA polymerase ε that has one or more amino acid residue mutations, wherein the amino acid residue mutations include a mutation that substitutes the leucine residue at the 952-position of the amino acid sequence of human DNA polymerase ε with another amino acid residue. Thus, a novel biomarker enabling the discrimination of a hyper-mutation type cancer is provided.
(FR) L'invention concerne une ADN polymérase epsilon humaine mutante qui présente une ou plusieurs mutations de résidus d'acides aminés, dont une mutation qui remplace le résidu leucine à la position 952 de la séquence d'acides aminés de l'ADN polymérase epsilon humaine par un autre résidu d'acide aminé. On obtient ainsi un nouveau biomarqueur assurant la discrimination d'un cancer de type hyper-mutation.
(JA) 本発明は、1つ以上のアミノ酸残基の変異を含む変異型ヒトDNAポリメラーゼεであって、アミノ酸残基の変異が、ヒトDNAポリメラーゼεのアミノ酸配列の第952番目のロイシン残基が他のアミノ酸残基になる変異を含む、変異型ヒトDNAポリメラーゼεを提供する。かかる方法によれば、高頻度変異型の癌を判別できる新たなバイオマーカーが提供される。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)