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1. (WO2018078533) ENGINEERED BIOCOMPATIBLE ANTIBIOTIC PARTICLES AND THEIR USE AGAINST URINARY TRACT INFECTION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/078533    International Application No.:    PCT/IB2017/056604
Publication Date: 03.05.2018 International Filing Date: 25.10.2017
IPC:
A61K 9/14 (2006.01), A61K 47/34 (2017.01), A61K 31/47 (2006.01), A61K 31/5383 (2006.01)
Applicants: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL [US/US]; 109 Church Street Chapel Hill, North Carolina 27516 (US).
DUKE UNIVERSITY [US/US]; Office of Licensing & Ventures Box 90083 Durham, North Carolina 27708 (US)
Inventors: DESIMONE, Joseph; (US).
LUFT, James; (US).
WANG, Ying; (US).
SEED, Patrick; (US)
Agent: WEST, Christopher; (US).
ALSTON & BIRD LLP; Alston & Bird LLP Bank of America Plaza 101 South Tryon Street, Suite 4000 Charlotte, North Carolina 28280-4000 (US).
SKELTON, Bryan L.; (US).
SCHILLING, Stephen H.; (US).
KEITH, Jason A.; (US).
CHANG, Cindy; (US)
Priority Data:
62/412,535 25.10.2016 US
Title (EN) ENGINEERED BIOCOMPATIBLE ANTIBIOTIC PARTICLES AND THEIR USE AGAINST URINARY TRACT INFECTION
(FR) PARTICULES ANTIBIOTIQUES BIOCOMPATIBLES MODIFIÉES ET LEUR UTILISATION CONTRE UNE INFECTION DES VOIES URINAIRES
Abstract: front page image
(EN)Described herein, to overcome the limitations of conventional antibiotics, antibiotics have been encapsulated in biocompatible particles manufactured using Particle Replication In Non-wetting Templates (PRINT). These PRINT antibiotic particles were assessed as a topical agent to prevent E. coli infection using in vitro and in vivo models relevant to UTI and neurogenic bladder. The results show a prolonged efficacy and wide distribution in the bladder, resulting in a prophylactic environment in the bladder. The subject matter described herein is directed to molded particles containing an antibiotic active agent and methods of treating diseases and conditions with the particles, and methods of preparing the particles and compositions comprising the particles.
(FR)Selon l'invention, en vue de surmonter les limitations d'antibiotiques classiques, des antibiotiques ont été encapsulés dans des particules biocompatibles fabriquées par réplication de particules dans des matrices non mouillantes (PRINT). Ces particules d'antibiotique PRINT ont été évaluées en tant qu'agent topique destiné à prévenir une infection par E. coli à l'aide de modèles in vitro et in vivo pertinents pour l'UTI et la vessie neurogène. Les résultats montrent une efficacité prolongée et une large distribution dans la vessie, permettant d'obtenir un environnement prophylactique dans la vessie. La présente invention concerne des particules moulées contenant un agent actif antibiotique et des méthodes de traitement de maladies et d'états pathologiques au moyen des particules, et des méthodes de préparation des particules et de compositions comprenant les particules.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)